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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RNF25 All Species: 20.61
Human Site: S231 Identified Species: 37.78
UniProt: Q96BH1 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96BH1 NP_071898.2 459 51219 S231 L Y Q P S A E S L R Q Q E E R
Chimpanzee Pan troglodytes XP_001158338 459 51203 S231 L Y Q P S V E S L R Q Q E E R
Rhesus Macaque Macaca mulatta XP_001090728 414 45939 I206 R Q Q E R G G I I D L E A E R
Dog Lupus familis XP_536071 459 51107 S231 L Y Q P S A E S L R Q Q E E R
Cat Felis silvestris
Mouse Mus musculus Q9QZR0 456 51208 S228 L Y Q P S A E S L R Q Q E E L
Rat Rattus norvegicus NP_001012004 454 50810 S226 L Y Q P S A E S L R Q Q E E L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001026430 410 46105 S202 P Q A P C Q A S A L E P A R A
Frog Xenopus laevis NP_001092170 377 42394 E169 T E Q K R S E E L S I L C P V
Zebra Danio Brachydanio rerio NP_957477 513 56750 S287 L P S S S P D S T S T I Q T S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610915 374 42153 K166 N Y Q E E F D K L P A W L Q K
Honey Bee Apis mellifera XP_624230 342 39095 Y134 D Q C A I C L Y G F R E G D E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_191589 366 41201 W158 H C E C I I R W W N W L H A Q
Baker's Yeast Sacchar. cerevisiae Q03768 265 31012 I57 V L T K E H T I I A E F K L P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.2 84.3 89.1 N.A. 82.3 84.5 N.A. N.A. 20.9 38.3 35.4 N.A. 27.2 29.6 N.A. N.A.
Protein Similarity: 100 98.6 86 93.2 N.A. 87.3 89.1 N.A. N.A. 32.6 54.9 51.4 N.A. 43.3 43.3 N.A. N.A.
P-Site Identity: 100 93.3 20 100 N.A. 93.3 93.3 N.A. N.A. 13.3 20 20 N.A. 20 0 N.A. N.A.
P-Site Similarity: 100 93.3 33.3 100 N.A. 93.3 93.3 N.A. N.A. 20 26.6 33.3 N.A. 40 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 23.9 20.7 N.A.
Protein Similarity: N.A. N.A. N.A. 38.1 32.2 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 8 0 31 8 0 8 8 8 0 16 8 8 % A
% Cys: 0 8 8 8 8 8 0 0 0 0 0 0 8 0 0 % C
% Asp: 8 0 0 0 0 0 16 0 0 8 0 0 0 8 0 % D
% Glu: 0 8 8 16 16 0 47 8 0 0 16 16 39 47 8 % E
% Phe: 0 0 0 0 0 8 0 0 0 8 0 8 0 0 0 % F
% Gly: 0 0 0 0 0 8 8 0 8 0 0 0 8 0 0 % G
% His: 8 0 0 0 0 8 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 0 0 16 8 0 16 16 0 8 8 0 0 0 % I
% Lys: 0 0 0 16 0 0 0 8 0 0 0 0 8 0 8 % K
% Leu: 47 8 0 0 0 0 8 0 54 8 8 16 8 8 16 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % N
% Pro: 8 8 0 47 0 8 0 0 0 8 0 8 0 8 8 % P
% Gln: 0 24 62 0 0 8 0 0 0 0 39 39 8 8 8 % Q
% Arg: 8 0 0 0 16 0 8 0 0 39 8 0 0 8 31 % R
% Ser: 0 0 8 8 47 8 0 54 0 16 0 0 0 0 8 % S
% Thr: 8 0 8 0 0 0 8 0 8 0 8 0 0 8 0 % T
% Val: 8 0 0 0 0 8 0 0 0 0 0 0 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 8 8 0 8 8 0 0 0 % W
% Tyr: 0 47 0 0 0 0 0 8 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _