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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APH1A
All Species:
12.42
Human Site:
S235
Identified Species:
24.85
UniProt:
Q96BI3
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96BI3
NP_001071096.1
265
28996
S235
A
F
I
T
A
G
G
S
L
R
S
I
Q
R
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001099903
222
24392
Y193
E
A
S
L
L
P
I
Y
A
V
T
V
S
M
G
Dog
Lupus familis
XP_540299
265
28985
S235
A
F
I
T
A
G
G
S
F
R
S
I
Q
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8BVF7
265
28967
S235
A
F
I
T
A
G
G
S
L
R
S
I
Q
R
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514807
225
24964
F196
L
L
M
G
V
W
A
F
F
T
A
G
G
S
L
Chicken
Gallus gallus
XP_001233302
256
28091
V226
V
L
M
A
I
A
A
V
W
A
Y
M
L
S
G
Frog
Xenopus laevis
NP_001089056
247
26905
Y218
E
A
S
L
I
P
I
Y
I
I
T
L
G
M
A
Zebra Danio
Brachydanio rerio
Q8JHE9
258
28628
Y229
S
V
M
A
V
W
A
Y
L
C
A
G
G
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VQG2
238
26419
N209
Y
T
T
T
L
L
I
N
Y
L
V
T
I
L
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O45876
308
33529
C247
L
L
I
C
I
A
Y
C
N
V
I
M
G
G
T
Sea Urchin
Strong. purpuratus
XP_783542
260
29305
A230
P
V
A
Y
V
T
L
A
V
M
T
L
F
A
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L9G7
250
27517
Y221
V
I
G
V
P
L
L
Y
L
V
A
S
L
T
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
83.4
99.2
N.A.
99.2
N.A.
N.A.
55.8
60.7
69.4
61.1
N.A.
40
N.A.
29.5
40.7
Protein Similarity:
100
N.A.
83.7
99.2
N.A.
99.6
N.A.
N.A.
71.6
75
83
79.2
N.A.
60.7
N.A.
48.7
56.2
P-Site Identity:
100
N.A.
0
93.3
N.A.
100
N.A.
N.A.
0
0
0
6.6
N.A.
6.6
N.A.
6.6
0
P-Site Similarity:
100
N.A.
13.3
93.3
N.A.
100
N.A.
N.A.
13.3
13.3
26.6
26.6
N.A.
20
N.A.
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
17
9
17
25
17
25
9
9
9
25
0
0
9
9
% A
% Cys:
0
0
0
9
0
0
0
9
0
9
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
17
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
25
0
0
0
0
0
9
17
0
0
0
9
0
9
% F
% Gly:
0
0
9
9
0
25
25
0
0
0
0
17
34
9
17
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
34
0
25
0
25
0
9
9
9
25
9
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
17
25
0
17
17
17
17
0
34
9
0
17
17
9
25
% L
% Met:
0
0
25
0
0
0
0
0
0
9
0
17
0
17
0
% M
% Asn:
0
0
0
0
0
0
0
9
9
0
0
0
0
0
0
% N
% Pro:
9
0
0
0
9
17
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
25
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
25
0
0
0
25
0
% R
% Ser:
9
0
17
0
0
0
0
25
0
0
25
9
9
25
25
% S
% Thr:
0
9
9
34
0
9
0
0
0
9
25
9
0
9
17
% T
% Val:
17
17
0
9
25
0
0
9
9
25
9
9
0
0
0
% V
% Trp:
0
0
0
0
0
17
0
0
9
0
0
0
0
0
0
% W
% Tyr:
9
0
0
9
0
0
9
34
9
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _