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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APH1A
All Species:
9.09
Human Site:
Y187
Identified Species:
18.18
UniProt:
Q96BI3
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96BI3
NP_001071096.1
265
28996
Y187
D
A
C
E
R
R
R
Y
W
A
L
G
L
V
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001099903
222
24392
L145
L
T
A
A
I
I
L
L
H
T
F
W
G
V
V
Dog
Lupus familis
XP_540299
265
28985
Y187
D
A
C
E
R
R
R
Y
W
A
L
G
L
V
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8BVF7
265
28967
Y187
D
A
C
E
R
R
R
Y
W
A
L
G
L
V
V
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514807
225
24964
A148
W
G
I
V
F
F
D
A
C
E
N
K
K
W
W
Chicken
Gallus gallus
XP_001233302
256
28091
F178
H
T
F
W
G
I
L
F
F
H
G
C
E
N
R
Frog
Xenopus laevis
NP_001089056
247
26905
L170
L
T
M
A
I
V
F
L
H
T
F
W
G
I
V
Zebra Danio
Brachydanio rerio
Q8JHE9
258
28628
A181
W
G
V
V
F
F
E
A
C
E
R
Q
R
W
W
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VQG2
238
26419
H161
A
L
S
I
I
L
L
H
T
F
W
S
V
I
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O45876
308
33529
R199
D
S
C
H
K
I
G
R
I
P
S
A
F
V
P
Sea Urchin
Strong. purpuratus
XP_783542
260
29305
V182
L
L
H
I
M
W
N
V
I
F
Y
W
G
F
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L9G7
250
27517
F173
A
F
V
T
I
H
T
F
S
M
V
I
A
F
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
83.4
99.2
N.A.
99.2
N.A.
N.A.
55.8
60.7
69.4
61.1
N.A.
40
N.A.
29.5
40.7
Protein Similarity:
100
N.A.
83.7
99.2
N.A.
99.6
N.A.
N.A.
71.6
75
83
79.2
N.A.
60.7
N.A.
48.7
56.2
P-Site Identity:
100
N.A.
13.3
100
N.A.
100
N.A.
N.A.
0
0
6.6
0
N.A.
0
N.A.
20
0
P-Site Similarity:
100
N.A.
13.3
100
N.A.
100
N.A.
N.A.
0
13.3
13.3
0
N.A.
20
N.A.
33.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
25
9
17
0
0
0
17
0
25
0
9
9
0
0
% A
% Cys:
0
0
34
0
0
0
0
0
17
0
0
9
0
0
0
% C
% Asp:
34
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
25
0
0
9
0
0
17
0
0
9
0
17
% E
% Phe:
0
9
9
0
17
17
9
17
9
17
17
0
9
17
9
% F
% Gly:
0
17
0
0
9
0
9
0
0
0
9
25
25
0
0
% G
% His:
9
0
9
9
0
9
0
9
17
9
0
0
0
0
0
% H
% Ile:
0
0
9
17
34
25
0
0
17
0
0
9
0
17
0
% I
% Lys:
0
0
0
0
9
0
0
0
0
0
0
9
9
0
0
% K
% Leu:
25
17
0
0
0
9
25
17
0
0
25
0
25
0
0
% L
% Met:
0
0
9
0
9
0
0
0
0
9
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
9
0
0
0
9
0
0
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
9
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% Q
% Arg:
0
0
0
0
25
25
25
9
0
0
9
0
9
0
9
% R
% Ser:
0
9
9
0
0
0
0
0
9
0
9
9
0
0
0
% S
% Thr:
0
25
0
9
0
0
9
0
9
17
0
0
0
0
0
% T
% Val:
0
0
17
17
0
9
0
9
0
0
9
0
9
42
42
% V
% Trp:
17
0
0
9
0
9
0
0
25
0
9
25
0
17
17
% W
% Tyr:
0
0
0
0
0
0
0
25
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _