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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHMP4C All Species: 27.88
Human Site: S21 Identified Species: 47.18
UniProt: Q96CF2 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96CF2 NP_689497.1 233 26411 S21 S K S R A A P S P Q E A L V R
Chimpanzee Pan troglodytes XP_528179 346 37934 S134 S K S R A A P S P Q E A L V R
Rhesus Macaque Macaca mulatta XP_001093735 233 26393 S21 S K S R A A P S P Q E A L A R
Dog Lupus familis XP_535115 236 26393 S21 S K G R A A P S P Q E A L A R
Cat Felis silvestris
Mouse Mus musculus Q9D7F7 232 26261 S21 S R A R A A P S A Q E A L A R
Rat Rattus norvegicus Q569C1 232 26305 S21 S R A R A A P S A Q E A L A R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507822 358 38284 S90 T A P G R P G S P D R G R A R
Chicken Gallus gallus Q5ZHP5 227 25137 S23 K G A G K G P S P Q E A I Q R
Frog Xenopus laevis Q6GNN8 227 25461 S25 S K N R K G P S A Q E A L F K
Zebra Danio Brachydanio rerio Q6IQ73 224 25158 Q21 G G K G P T P Q E A I Q K L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610462 226 25425 A21 V A P T T G E A I Q K L R E T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SZE4 219 24314 L22 A L Q T L D K L N E T L E M L
Baker's Yeast Sacchar. cerevisiae P39929 240 26969 R25 S P T K A I V R L R E H I N L
Red Bread Mold Neurospora crassa Q871Y8 228 24957 P21 A Q K R K D S P K N A I L G L
Conservation
Percent
Protein Identity: 100 67 98.7 88.1 N.A. 86.6 87.1 N.A. 41.3 64.3 71.2 63.5 N.A. 49.3 N.A. N.A. N.A.
Protein Similarity: 100 67.3 99.5 91 N.A. 92.6 93.1 N.A. 50.8 79.4 83.2 79.8 N.A. 69 N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 86.6 N.A. 73.3 73.3 N.A. 20 46.6 60 13.3 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 86.6 N.A. 86.6 86.6 N.A. 26.6 60 73.3 20 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 33.4 34.1 32.1
Protein Similarity: N.A. N.A. N.A. 53.2 57 57
P-Site Identity: N.A. N.A. N.A. 0 20 13.3
P-Site Similarity: N.A. N.A. N.A. 20 46.6 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 15 22 0 50 43 0 8 22 8 8 58 0 36 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 15 0 0 0 8 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 8 0 8 8 65 0 8 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 8 15 8 22 0 22 8 0 0 0 0 8 0 8 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 0 8 0 8 8 15 0 0 % I
% Lys: 8 36 15 8 22 0 8 0 8 0 8 0 8 0 8 % K
% Leu: 0 8 0 0 8 0 0 8 8 0 0 15 58 8 22 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 0 8 0 0 0 0 0 8 8 0 0 0 8 0 % N
% Pro: 0 8 15 0 8 8 65 8 43 0 0 0 0 0 0 % P
% Gln: 0 8 8 0 0 0 0 8 0 65 0 8 0 8 0 % Q
% Arg: 0 15 0 58 8 0 0 8 0 8 8 0 15 0 65 % R
% Ser: 58 0 22 0 0 0 8 65 0 0 0 0 0 0 0 % S
% Thr: 8 0 8 15 8 8 0 0 0 0 8 0 0 0 8 % T
% Val: 8 0 0 0 0 0 8 0 0 0 0 0 0 15 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _