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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
OPTN
All Species:
28.79
Human Site:
S177
Identified Species:
63.33
UniProt:
Q96CV9
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96CV9
NP_001008212.1
577
65922
S177
S
S
G
S
S
E
D
S
F
V
E
I
R
M
A
Chimpanzee
Pan troglodytes
XP_001139979
577
66063
S177
S
S
G
S
S
E
D
S
F
V
E
I
R
M
A
Rhesus Macaque
Macaca mulatta
Q861Q8
571
65086
S177
S
S
G
S
S
E
D
S
F
V
E
I
R
M
A
Dog
Lupus familis
XP_857661
579
66273
S177
S
G
G
P
S
E
D
S
F
V
E
I
R
I
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8K3K8
584
66999
S187
S
G
G
S
S
E
D
S
F
V
E
I
R
M
T
Rat
Rattus norvegicus
Q8R5M4
585
66995
S188
S
G
G
S
S
E
D
S
F
V
E
I
R
M
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515698
575
65986
S177
S
T
G
S
S
E
D
S
F
V
E
I
R
M
A
Chicken
Gallus gallus
Q90Z16
556
64069
S169
N
I
A
S
A
E
D
S
F
V
E
I
G
M
N
Frog
Xenopus laevis
Q5M7B7
532
61496
K168
G
E
I
V
N
E
E
K
A
N
K
I
L
S
D
Zebra Danio
Brachydanio rerio
Q5RI56
517
59044
E166
K
D
L
S
S
V
P
E
A
S
A
F
S
M
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9GYV5
387
43861
A40
Q
E
A
E
E
T
V
A
S
T
S
T
Q
P
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
95.8
84.6
N.A.
78.4
80.1
N.A.
73.4
57.5
44.1
41
N.A.
20.6
N.A.
N.A.
N.A.
Protein Similarity:
100
99.3
97.2
90.8
N.A.
86.6
87.3
N.A.
83.5
73.1
61
59.6
N.A.
36.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
86.6
86.6
N.A.
93.3
60
13.3
20
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
100
73.3
33.3
20
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
19
0
10
0
0
10
19
0
10
0
0
0
46
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
73
0
0
0
0
0
0
0
10
% D
% Glu:
0
19
0
10
10
82
10
10
0
0
73
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
73
0
0
10
0
0
0
% F
% Gly:
10
28
64
0
0
0
0
0
0
0
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
10
0
0
0
0
0
0
0
0
82
0
10
0
% I
% Lys:
10
0
0
0
0
0
0
10
0
0
10
0
0
0
0
% K
% Leu:
0
0
10
0
0
0
0
0
0
0
0
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
73
0
% M
% Asn:
10
0
0
0
10
0
0
0
0
10
0
0
0
0
10
% N
% Pro:
0
0
0
10
0
0
10
0
0
0
0
0
0
10
19
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
64
0
0
% R
% Ser:
64
28
0
73
73
0
0
73
10
10
10
0
10
10
0
% S
% Thr:
0
10
0
0
0
10
0
0
0
10
0
10
0
0
19
% T
% Val:
0
0
0
10
0
10
10
0
0
73
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _