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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MSI2 All Species: 13.64
Human Site: S293 Identified Species: 25
UniProt: Q96DH6 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96DH6 NP_620412.1 328 35197 S293 Y G P A S Q D S G V G N Y I S
Chimpanzee Pan troglodytes XP_001162046 324 34904 S289 Y G P A S Q D S G V G N Y I S
Rhesus Macaque Macaca mulatta Q28521 320 34202 L286 G N F G G R S L G P Y G G G G
Dog Lupus familis XP_532379 324 34866 S289 Y G P A S Q D S G V G N Y I S
Cat Felis silvestris
Mouse Mus musculus Q920Q6 346 36920 G293 A R P G G F P G A N S P G P V
Rat Rattus norvegicus Q8K3P4 362 39115 S327 Y G A A N Q D S G V S S Y I S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506312 349 37295 G289 S N P A R P G G F P G A N S P
Chicken Gallus gallus Q5ZI72 301 33425 N267 Y S G Y N Y P N Y G Y G P G Y
Frog Xenopus laevis Q7ZX83 293 32595 Y259 S G Y D Y S G Y S Y G Y N P G
Zebra Danio Brachydanio rerio NP_997961 388 41982 H293 D Y A T L G P H T G Q M L Q S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVE5 369 40069 N331 Y S S A A A D N V G Y V Q A T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22037 346 36325 G312 W G G P Q Q G G G G G G W G G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q99383 534 59631 N447 D S D N N K S N D V Q T I G N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.5 30.1 92.6 N.A. 94.5 70.4 N.A. 88.2 37.2 37.5 78.6 N.A. 56.3 N.A. 30.9 N.A.
Protein Similarity: 100 95.1 46.9 94.8 N.A. 94.5 76.8 N.A. 88.8 49.3 48.1 80.6 N.A. 65.5 N.A. 46.8 N.A.
P-Site Identity: 100 100 6.6 100 N.A. 6.6 73.3 N.A. 20 6.6 13.3 6.6 N.A. 20 N.A. 26.6 N.A.
P-Site Similarity: 100 100 13.3 100 N.A. 6.6 86.6 N.A. 20 20 13.3 6.6 N.A. 40 N.A. 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 36.5 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 16 47 8 8 0 0 8 0 0 8 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 0 8 8 0 0 39 0 8 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 8 0 0 8 0 0 8 0 0 0 0 0 0 % F
% Gly: 8 47 16 16 16 8 24 24 47 31 47 24 16 31 24 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 8 31 0 % I
% Lys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 0 8 0 0 8 0 0 0 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 16 0 8 24 0 0 24 0 8 0 24 16 0 8 % N
% Pro: 0 0 39 8 0 8 24 0 0 16 0 8 8 16 8 % P
% Gln: 0 0 0 0 8 39 0 0 0 0 16 0 8 8 0 % Q
% Arg: 0 8 0 0 8 8 0 0 0 0 0 0 0 0 0 % R
% Ser: 16 24 8 0 24 8 16 31 8 0 16 8 0 8 39 % S
% Thr: 0 0 0 8 0 0 0 0 8 0 0 8 0 0 8 % T
% Val: 0 0 0 0 0 0 0 0 8 39 0 8 0 0 8 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 47 8 8 8 8 8 0 8 8 8 24 8 31 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _