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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MSI2 All Species: 17.88
Human Site: Y40 Identified Species: 32.78
UniProt: Q96DH6 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96DH6 NP_620412.1 328 35197 Y40 S P D S L R D Y F S K F G E I
Chimpanzee Pan troglodytes XP_001162046 324 34904 F40 L R D Y F S K F G E I R E C M
Rhesus Macaque Macaca mulatta Q28521 320 34202 G56 P N T K R S R G F G F V T Y A
Dog Lupus familis XP_532379 324 34866 F40 L R D Y F S K F G E I K K C M
Cat Felis silvestris
Mouse Mus musculus Q920Q6 346 36920 Y40 S P D S L R D Y F S K F G E I
Rat Rattus norvegicus Q8K3P4 362 39115 F40 Q E G L R E Y F G Q F G E V K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506312 349 37295 F40 L R D Y F S K F G E I R E C M
Chicken Gallus gallus Q5ZI72 301 33425 S42 G G L S W D T S K K D L T E Y
Frog Xenopus laevis Q7ZX83 293 32595 S34 K M F I G G L S W D T S K K D
Zebra Danio Brachydanio rerio NP_997961 388 41982 Y40 S P D S L R D Y F C K F G E I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVE5 369 40069 Y48 S P E S L R D Y F G R Y G D I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22037 346 36325 F42 T D D L M R E F Y S Q F G E I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q99383 534 59631 Y178 T E D N L R E Y F G K Y G T V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.5 30.1 92.6 N.A. 94.5 70.4 N.A. 88.2 37.2 37.5 78.6 N.A. 56.3 N.A. 30.9 N.A.
Protein Similarity: 100 95.1 46.9 94.8 N.A. 94.5 76.8 N.A. 88.8 49.3 48.1 80.6 N.A. 65.5 N.A. 46.8 N.A.
P-Site Identity: 100 6.6 6.6 6.6 N.A. 100 0 N.A. 6.6 13.3 0 93.3 N.A. 66.6 N.A. 46.6 N.A.
P-Site Similarity: 100 20 6.6 20 N.A. 100 6.6 N.A. 20 13.3 13.3 93.3 N.A. 93.3 N.A. 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 36.5 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 80 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 24 0 % C
% Asp: 0 8 62 0 0 8 31 0 0 8 8 0 0 8 8 % D
% Glu: 0 16 8 0 0 8 16 0 0 24 0 0 24 39 0 % E
% Phe: 0 0 8 0 24 0 0 39 47 0 16 31 0 0 0 % F
% Gly: 8 8 8 0 8 8 0 8 31 24 0 8 47 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 0 24 0 0 0 39 % I
% Lys: 8 0 0 8 0 0 24 0 8 8 31 8 16 8 8 % K
% Leu: 24 0 8 16 39 0 8 0 0 0 0 8 0 0 0 % L
% Met: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 24 % M
% Asn: 0 8 0 8 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 8 31 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % Q
% Arg: 0 24 0 0 16 47 8 0 0 0 8 16 0 0 0 % R
% Ser: 31 0 0 39 0 31 0 16 0 24 0 8 0 0 0 % S
% Thr: 16 0 8 0 0 0 8 0 0 0 8 0 16 8 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 8 0 8 8 % V
% Trp: 0 0 0 0 8 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 24 0 0 8 39 8 0 0 16 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _