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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ITPKC
All Species:
6.36
Human Site:
S181
Identified Species:
14
UniProt:
Q96DU7
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96DU7
NP_079470.1
683
75207
S181
T
E
L
E
T
H
G
S
Q
T
Q
P
E
R
V
Chimpanzee
Pan troglodytes
XP_524271
683
75280
S181
T
E
L
E
T
H
G
S
Q
T
Q
P
E
R
V
Rhesus Macaque
Macaca mulatta
XP_001092036
566
61727
T91
S
S
Q
T
E
F
W
T
D
G
Q
T
E
P
S
Dog
Lupus familis
XP_855312
621
68771
A143
S
Q
T
Q
P
E
R
A
K
T
W
A
H
N
L
Cat
Felis silvestris
Mouse
Mus musculus
Q7TS72
678
74474
M179
T
E
L
D
R
S
D
M
W
Q
T
L
P
E
R
Rat
Rattus norvegicus
Q80ZG2
678
74445
Q181
L
D
R
S
E
L
W
Q
T
L
P
E
R
D
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415039
637
69972
R142
S
P
P
P
S
S
P
R
P
S
S
P
Q
P
S
Frog
Xenopus laevis
NP_001088157
516
58252
N41
N
V
H
Q
T
R
Q
N
S
Q
P
L
H
L
P
Zebra Danio
Brachydanio rerio
XP_691475
657
73298
P152
S
R
E
V
Q
R
S
P
R
I
S
R
K
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572875
669
73198
S148
D
S
G
R
R
P
T
S
A
D
S
E
D
A
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_795627
356
40840
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
79.6
75.8
N.A.
75.5
75.5
N.A.
N.A.
38.2
39.8
39.2
N.A.
33.5
N.A.
N.A.
29.8
Protein Similarity:
100
99.4
80.2
79.6
N.A.
81.2
81.2
N.A.
N.A.
52.2
51.2
52.4
N.A.
48.6
N.A.
N.A.
39
P-Site Identity:
100
100
13.3
6.6
N.A.
20
0
N.A.
N.A.
6.6
6.6
0
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
100
26.6
46.6
N.A.
26.6
6.6
N.A.
N.A.
33.3
20
20
N.A.
13.3
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
10
0
0
10
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
10
0
0
10
0
10
10
0
0
10
10
0
% D
% Glu:
0
28
10
19
19
10
0
0
0
0
0
19
28
10
0
% E
% Phe:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
0
0
0
19
0
0
10
0
0
0
0
10
% G
% His:
0
0
10
0
0
19
0
0
0
0
0
0
19
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
10
0
0
0
10
0
10
% K
% Leu:
10
0
28
0
0
10
0
0
0
10
0
19
0
10
10
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
10
0
0
0
0
0
10
0
% N
% Pro:
0
10
10
10
10
10
10
10
10
0
19
28
10
19
19
% P
% Gln:
0
10
10
19
10
0
10
10
19
19
28
0
10
0
0
% Q
% Arg:
0
10
10
10
19
19
10
10
10
0
0
10
10
19
10
% R
% Ser:
37
19
0
10
10
19
10
28
10
10
28
0
0
10
19
% S
% Thr:
28
0
10
10
28
0
10
10
10
28
10
10
0
0
0
% T
% Val:
0
10
0
10
0
0
0
0
0
0
0
0
0
0
19
% V
% Trp:
0
0
0
0
0
0
19
0
10
0
10
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _