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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MRRF All Species: 18.18
Human Site: S239 Identified Species: 40
UniProt: Q96E11 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96E11 NP_620132.1 262 29277 S239 R L I E K Q I S Q M A D D T V
Chimpanzee Pan troglodytes XP_001135996 262 29306 S239 R L I E K Q I S Q M A D D T V
Rhesus Macaque Macaca mulatta XP_001089220 292 32097 R244 P Q V T R E H R E T L V K L A
Dog Lupus familis XP_537859 262 29135 S239 R L I E K Q I S Q M A D D T V
Cat Felis silvestris
Mouse Mus musculus Q9D6S7 262 29032 S239 R L I E K Q I S Q M A D D T V
Rat Rattus norvegicus Q5RKI9 262 29133 S239 R L I E K Q I S Q M A D D T V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512325 241 26791 Q219 L I E K K I G Q M A D D M V A
Chicken Gallus gallus XP_415395 259 28549 Q236 W L L E K Q I Q Q M A D S A A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001002174 257 28422 Q234 H L I E K Q I Q Q M T D S F T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648302 254 28466 A231 A A Q A Q V T A I A D R F I S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_792740 188 20763 V166 L E Q Q I H Q V T D T F N D S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 77.7 87.7 N.A. 85.1 85.1 N.A. 70.9 61.8 N.A. 57.6 N.A. 32.8 N.A. N.A. 36.6
Protein Similarity: 100 98.8 79.7 93.8 N.A. 92.7 91.2 N.A. 83.5 76.7 N.A. 74.4 N.A. 56.1 N.A. N.A. 52.6
P-Site Identity: 100 100 0 100 N.A. 100 100 N.A. 13.3 60 N.A. 60 N.A. 0 N.A. N.A. 0
P-Site Similarity: 100 100 26.6 100 N.A. 100 100 N.A. 26.6 66.6 N.A. 60 N.A. 13.3 N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 10 0 0 0 10 0 19 55 0 0 10 28 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 10 19 73 46 10 0 % D
% Glu: 0 10 10 64 0 10 0 0 10 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 10 10 10 0 % F
% Gly: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % G
% His: 10 0 0 0 0 10 10 0 0 0 0 0 0 0 0 % H
% Ile: 0 10 55 0 10 10 64 0 10 0 0 0 0 10 0 % I
% Lys: 0 0 0 10 73 0 0 0 0 0 0 0 10 0 0 % K
% Leu: 19 64 10 0 0 0 0 0 0 0 10 0 0 10 0 % L
% Met: 0 0 0 0 0 0 0 0 10 64 0 0 10 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % N
% Pro: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 10 19 10 10 64 10 28 64 0 0 0 0 0 0 % Q
% Arg: 46 0 0 0 10 0 0 10 0 0 0 10 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 46 0 0 0 0 19 0 19 % S
% Thr: 0 0 0 10 0 0 10 0 10 10 19 0 0 46 10 % T
% Val: 0 0 10 0 0 10 0 10 0 0 0 10 0 10 46 % V
% Trp: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _