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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIRT1 All Species: 19.09
Human Site: S159 Identified Species: 35
UniProt: Q96EB6 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96EB6 NP_001135970.1 747 81681 S159 I I T N G F H S C E S D E E D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001087854 741 80936 S155 I I T N G F H S C E S D E E D
Dog Lupus familis XP_546130 745 81496 S155 I I T N G F H S C E S D E D D
Cat Felis silvestris
Mouse Mus musculus Q923E4 737 80353 S151 L L T N G F H S C E S D D D D
Rat Rattus norvegicus Q5RJQ4 350 39301
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508324 480 51688
Chicken Gallus gallus NP_001004767 756 82614 S170 I I A N G F H S C D S D E D D
Frog Xenopus laevis NP_001091195 710 78684 H135 D D L A G G F H S C D S D D D
Zebra Danio Brachydanio rerio Q7ZVK3 379 42296
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477351 823 91818 I127 E E D D E E G I T G T S N E D
Honey Bee Apis mellifera XP_395386 868 98678 S109 D E V S S T V S N L S D L S G
Nematode Worm Caenorhab. elegans Q21921 607 68747 A101 Q I F P D F N A S R I A T M S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53685 503 57684
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 93.3 91.4 N.A. 85.1 23.4 N.A. 49.7 68.1 57.9 22.2 N.A. 37.2 39.9 31.3 N.A.
Protein Similarity: 100 N.A. 95.5 94.3 N.A. 90 33.3 N.A. 54.7 75.4 69.3 35 N.A. 52.2 55.9 47.5 N.A.
P-Site Identity: 100 N.A. 100 93.3 N.A. 73.3 0 N.A. 0 80 13.3 0 N.A. 13.3 20 13.3 N.A.
P-Site Similarity: 100 N.A. 100 100 N.A. 100 0 N.A. 0 93.3 26.6 0 N.A. 26.6 26.6 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 22.2 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 35.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 8 0 0 0 8 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 39 8 0 0 0 0 0 % C
% Asp: 16 8 8 8 8 0 0 0 0 8 8 47 16 31 54 % D
% Glu: 8 16 0 0 8 8 0 0 0 31 0 0 31 24 0 % E
% Phe: 0 0 8 0 0 47 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 47 8 8 0 0 8 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 39 8 0 0 0 0 0 0 0 % H
% Ile: 31 39 0 0 0 0 0 8 0 0 8 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 8 8 8 0 0 0 0 0 0 8 0 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 0 0 39 0 0 8 0 8 0 0 0 8 0 0 % N
% Pro: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % R
% Ser: 0 0 0 8 8 0 0 47 16 0 47 16 0 8 8 % S
% Thr: 0 0 31 0 0 8 0 0 8 0 8 0 8 0 0 % T
% Val: 0 0 8 0 0 0 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _