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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT1
All Species:
23.64
Human Site:
S169
Identified Species:
43.33
UniProt:
Q96EB6
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EB6
NP_001135970.1
747
81681
S169
S
D
E
E
D
R
A
S
H
A
S
S
S
D
W
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087854
741
80936
S165
S
D
E
E
D
R
A
S
H
A
S
S
S
D
W
Dog
Lupus familis
XP_546130
745
81496
S165
S
D
E
D
D
R
A
S
H
A
S
S
S
D
W
Cat
Felis silvestris
Mouse
Mus musculus
Q923E4
737
80353
S161
S
D
D
D
D
R
T
S
H
A
S
S
S
D
W
Rat
Rattus norvegicus
Q5RJQ4
350
39301
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508324
480
51688
Chicken
Gallus gallus
NP_001004767
756
82614
S180
S
D
E
D
D
R
A
S
H
A
S
S
S
D
W
Frog
Xenopus laevis
NP_001091195
710
78684
S145
D
S
D
D
D
G
A
S
H
A
S
S
S
D
W
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477351
823
91818
S137
T
S
N
E
D
E
D
S
S
S
N
C
S
S
S
Honey Bee
Apis mellifera
XP_395386
868
98678
D119
S
D
L
S
G
L
S
D
F
S
G
E
G
D
I
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
A111
I
A
T
M
S
E
N
A
H
F
A
I
L
S
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53685
503
57684
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.3
91.4
N.A.
85.1
23.4
N.A.
49.7
68.1
57.9
22.2
N.A.
37.2
39.9
31.3
N.A.
Protein Similarity:
100
N.A.
95.5
94.3
N.A.
90
33.3
N.A.
54.7
75.4
69.3
35
N.A.
52.2
55.9
47.5
N.A.
P-Site Identity:
100
N.A.
100
93.3
N.A.
80
0
N.A.
0
93.3
66.6
0
N.A.
26.6
20
6.6
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
93.3
0
N.A.
0
100
80
0
N.A.
46.6
33.3
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
39
8
0
47
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
8
47
16
31
54
0
8
8
0
0
0
0
0
54
8
% D
% Glu:
0
0
31
24
0
16
0
0
0
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
8
0
0
0
0
8
0
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
54
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
8
0
0
8
0
0
0
0
0
0
8
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
8
0
0
0
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
39
0
0
0
0
0
0
0
0
0
% R
% Ser:
47
16
0
8
8
0
8
54
8
16
47
47
54
16
8
% S
% Thr:
8
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
47
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _