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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT1
All Species:
31.82
Human Site:
S441
Identified Species:
58.33
UniProt:
Q96EB6
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EB6
NP_001135970.1
747
81681
S441
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087854
741
80936
S435
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
Dog
Lupus familis
XP_546130
745
81496
S437
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
Cat
Felis silvestris
Mouse
Mus musculus
Q923E4
737
80353
S433
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
Rat
Rattus norvegicus
Q5RJQ4
350
39301
P78
E
K
Y
H
L
P
Y
P
E
A
I
F
E
I
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508324
480
51688
N208
G
D
C
D
V
I
I
N
E
L
C
Q
R
L
G
Chicken
Gallus gallus
NP_001004767
756
82614
S452
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
Frog
Xenopus laevis
NP_001091195
710
78684
S417
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
K107
G
L
Y
A
N
L
Q
K
Y
N
L
P
Y
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477351
823
91818
S428
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
Honey Bee
Apis mellifera
XP_395386
868
98678
S384
D
L
L
I
V
I
G
S
S
L
K
V
R
P
V
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
V335
S
S
L
K
V
R
P
V
A
L
I
P
H
C
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53685
503
57684
R231
E
G
F
Y
S
K
I
R
H
L
G
L
E
D
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.3
91.4
N.A.
85.1
23.4
N.A.
49.7
68.1
57.9
22.2
N.A.
37.2
39.9
31.3
N.A.
Protein Similarity:
100
N.A.
95.5
94.3
N.A.
90
33.3
N.A.
54.7
75.4
69.3
35
N.A.
52.2
55.9
47.5
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
0
N.A.
26.6
100
100
13.3
N.A.
100
100
26.6
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
13.3
N.A.
33.3
100
100
20
N.A.
100
100
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
22.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
8
8
0
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
8
0
0
8
0
% C
% Asp:
62
8
0
8
0
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
16
0
0
0
0
0
0
0
16
0
0
0
16
0
8
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
16
8
0
0
0
0
62
0
0
0
8
0
0
0
8
% G
% His:
0
0
0
8
0
0
0
0
8
0
0
0
8
0
0
% H
% Ile:
0
0
0
62
0
70
16
0
0
0
16
0
0
8
0
% I
% Lys:
0
8
0
8
0
8
0
8
0
0
62
0
0
0
0
% K
% Leu:
0
70
70
0
8
8
0
0
0
85
8
8
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
8
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
8
8
8
0
0
0
16
0
70
8
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
8
0
8
0
0
0
0
70
0
0
% R
% Ser:
8
8
0
0
8
0
0
62
62
0
0
0
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
77
0
0
8
0
0
0
62
0
0
70
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
16
8
0
0
8
0
8
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _