KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SEH1L
All Species:
10.61
Human Site:
S349
Identified Species:
21.21
UniProt:
Q96EE3
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EE3
NP_001013455.1
360
39649
S349
T
I
P
S
L
Q
N
S
L
N
G
S
S
A
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_860726
360
39739
S349
S
I
P
N
L
Q
N
S
L
N
G
S
S
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8R2U0
360
39756
S349
N
I
P
N
L
Q
N
S
L
N
G
T
S
A
S
Rat
Rattus norvegicus
Q5XFW8
322
35529
A312
K
G
Q
G
S
V
S
A
S
I
T
E
G
Q
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516945
324
35581
L314
N
P
N
L
Q
N
S
L
N
G
S
S
A
G
R
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4FZW5
360
39707
V349
G
Q
S
L
Q
N
S
V
N
G
T
P
S
S
G
Zebra Danio
Brachydanio rerio
Q6TGU2
364
39798
V349
P
G
A
A
Q
M
I
V
G
A
A
T
A
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610343
354
39496
K344
A
T
A
K
F
Y
K
K
G
T
I
G
N
Q
V
Honey Bee
Apis mellifera
XP_396810
408
45120
T349
I
Q
Q
T
S
S
T
T
R
A
I
T
I
A
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781224
444
49387
S349
T
H
R
G
R
N
T
S
S
S
A
N
Q
Q
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53011
349
39104
F339
K
A
T
Y
S
N
E
F
K
C
M
S
V
I
T
Red Bread Mold
Neurospora crassa
Q7RZF5
304
33367
G294
L
W
K
E
N
L
K
G
E
W
E
N
V
K
T
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
98
N.A.
96.1
29.7
N.A.
86.3
N.A.
90.8
81.8
N.A.
53
58.5
N.A.
57.4
Protein Similarity:
100
N.A.
N.A.
99.1
N.A.
98
48.3
N.A.
87.7
N.A.
95.5
89
N.A.
70.5
72.3
N.A.
66.6
P-Site Identity:
100
N.A.
N.A.
73.3
N.A.
73.3
0
N.A.
6.6
N.A.
13.3
0
N.A.
0
6.6
N.A.
13.3
P-Site Similarity:
100
N.A.
N.A.
93.3
N.A.
86.6
13.3
N.A.
20
N.A.
26.6
20
N.A.
6.6
26.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.5
26.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.3
43.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
0
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
6.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
17
9
0
0
0
9
0
17
17
0
17
25
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
9
0
0
9
0
9
0
9
9
0
0
0
% E
% Phe:
0
0
0
0
9
0
0
9
0
0
0
0
0
0
0
% F
% Gly:
9
17
0
17
0
0
0
9
17
17
25
9
9
17
17
% G
% His:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
9
25
0
0
0
0
9
0
0
9
17
0
9
9
0
% I
% Lys:
17
0
9
9
0
0
17
9
9
0
0
0
0
9
0
% K
% Leu:
9
0
0
17
25
9
0
9
25
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
9
0
0
0
0
9
0
0
0
0
% M
% Asn:
17
0
9
17
9
34
25
0
17
25
0
17
9
0
0
% N
% Pro:
9
9
25
0
0
0
0
0
0
0
0
9
0
0
0
% P
% Gln:
0
17
17
0
25
25
0
0
0
0
0
0
9
25
17
% Q
% Arg:
0
0
9
0
9
0
0
0
9
0
0
0
0
0
17
% R
% Ser:
9
0
9
9
25
9
25
34
17
9
9
34
34
17
17
% S
% Thr:
17
9
9
9
0
0
17
9
0
9
17
25
0
0
25
% T
% Val:
0
0
0
0
0
9
0
17
0
0
0
0
17
0
9
% V
% Trp:
0
9
0
0
0
0
0
0
0
9
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
9
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _