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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SEH1L
All Species:
19.09
Human Site:
T249
Identified Species:
38.18
UniProt:
Q96EE3
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EE3
NP_001013455.1
360
39649
T249
T
K
D
V
R
I
F
T
L
K
P
V
R
K
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_860726
360
39739
T249
T
K
D
V
R
I
F
T
L
K
P
V
R
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8R2U0
360
39756
T249
T
K
D
V
R
I
F
T
L
K
P
L
R
K
E
Rat
Rattus norvegicus
Q5XFW8
322
35529
S212
E
Q
K
L
E
A
H
S
D
W
V
R
D
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516945
324
35581
K214
D
V
R
I
F
T
L
K
P
V
R
K
E
L
T
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4FZW5
360
39707
T249
T
K
D
V
R
I
F
T
M
K
P
L
R
K
E
Zebra Danio
Brachydanio rerio
Q6TGU2
364
39798
K249
T
K
D
V
R
I
F
K
L
L
P
L
R
R
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610343
354
39496
L244
L
A
V
A
S
K
D
L
Y
I
V
N
L
R
G
Honey Bee
Apis mellifera
XP_396810
408
45120
T249
S
N
D
V
Q
I
I
T
L
K
P
T
L
D
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781224
444
49387
K249
D
V
R
I
M
T
L
K
P
M
R
D
Q
F
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53011
349
39104
R239
A
T
G
C
K
D
G
R
I
R
I
F
K
I
T
Red Bread Mold
Neurospora crassa
Q7RZF5
304
33367
T194
D
N
L
L
K
I
W
T
F
D
P
A
T
N
G
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
98
N.A.
96.1
29.7
N.A.
86.3
N.A.
90.8
81.8
N.A.
53
58.5
N.A.
57.4
Protein Similarity:
100
N.A.
N.A.
99.1
N.A.
98
48.3
N.A.
87.7
N.A.
95.5
89
N.A.
70.5
72.3
N.A.
66.6
P-Site Identity:
100
N.A.
N.A.
100
N.A.
93.3
0
N.A.
0
N.A.
86.6
73.3
N.A.
0
46.6
N.A.
0
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
100
20
N.A.
6.6
N.A.
100
86.6
N.A.
6.6
60
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.5
26.1
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.3
43.3
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
20
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
40
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
9
0
9
0
0
0
0
0
9
0
0
9
% A
% Cys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
25
0
50
0
0
9
9
0
9
9
0
9
9
9
0
% D
% Glu:
9
0
0
0
9
0
0
0
0
0
0
0
9
0
42
% E
% Phe:
0
0
0
0
9
0
42
0
9
0
0
9
0
9
0
% F
% Gly:
0
0
9
0
0
0
9
0
0
0
0
0
0
0
17
% G
% His:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
17
0
59
9
0
9
9
9
0
0
9
0
% I
% Lys:
0
42
9
0
17
9
0
25
0
42
0
9
9
34
0
% K
% Leu:
9
0
9
17
0
0
17
9
42
9
0
25
17
9
0
% L
% Met:
0
0
0
0
9
0
0
0
9
9
0
0
0
0
0
% M
% Asn:
0
17
0
0
0
0
0
0
0
0
0
9
0
9
0
% N
% Pro:
0
0
0
0
0
0
0
0
17
0
59
0
0
0
0
% P
% Gln:
0
9
0
0
9
0
0
0
0
0
0
0
9
0
0
% Q
% Arg:
0
0
17
0
42
0
0
9
0
9
17
9
42
17
0
% R
% Ser:
9
0
0
0
9
0
0
9
0
0
0
0
0
0
9
% S
% Thr:
42
9
0
0
0
17
0
50
0
0
0
9
9
0
17
% T
% Val:
0
17
9
50
0
0
0
0
0
9
17
17
0
9
9
% V
% Trp:
0
0
0
0
0
0
9
0
0
9
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _