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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SEH1L All Species: 19.7
Human Site: Y209 Identified Species: 39.39
UniProt: Q96EE3 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96EE3 NP_001013455.1 360 39649 Y209 Y N E N T R K Y A K A E T L M
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_860726 360 39739 Y209 Y N E N T R K Y A K A E T L M
Cat Felis silvestris
Mouse Mus musculus Q8R2U0 360 39756 Y209 Y N E N T R K Y A K A E T L M
Rat Rattus norvegicus Q5XFW8 322 35529 S172 G S L I D Q P S G Q K P N Y I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516945 324 35581 K174 E N T R K Y A K A E T L M T V
Chicken Gallus gallus
Frog Xenopus laevis Q4FZW5 360 39707 Y209 Y N E N T R K Y A K A E T L M
Zebra Danio Brachydanio rerio Q6TGU2 364 39798 Y209 Y N E N T R K Y A K A E T L M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610343 354 39496 N204 F L F A Y S E N S R K C V K I
Honey Bee Apis mellifera XP_396810 408 45120 R209 E Y S E S S R R W T K T Q T L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781224 444 49387 K209 E N E R K W Q K I D T L N V I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53011 349 39104 D199 I I Y Q R G K D G K L H V A A
Red Bread Mold Neurospora crassa Q7RZF5 304 33367 S154 A H G L G V N S V S W A P A T
Conservation
Percent
Protein Identity: 100 N.A. N.A. 98 N.A. 96.1 29.7 N.A. 86.3 N.A. 90.8 81.8 N.A. 53 58.5 N.A. 57.4
Protein Similarity: 100 N.A. N.A. 99.1 N.A. 98 48.3 N.A. 87.7 N.A. 95.5 89 N.A. 70.5 72.3 N.A. 66.6
P-Site Identity: 100 N.A. N.A. 100 N.A. 100 0 N.A. 13.3 N.A. 100 100 N.A. 0 0 N.A. 13.3
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 26.6 N.A. 26.6 N.A. 100 100 N.A. 33.3 20 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27.5 26.1
Protein Similarity: N.A. N.A. N.A. N.A. 46.3 43.3
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 0
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 9 0 0 9 0 50 0 42 9 0 17 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 0 0 0 0 9 0 0 9 0 9 0 0 0 0 0 % D
% Glu: 25 0 50 9 0 0 9 0 0 9 0 42 0 0 0 % E
% Phe: 9 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 9 0 9 0 9 9 0 0 17 0 0 0 0 0 0 % G
% His: 0 9 0 0 0 0 0 0 0 0 0 9 0 0 0 % H
% Ile: 9 9 0 9 0 0 0 0 9 0 0 0 0 0 25 % I
% Lys: 0 0 0 0 17 0 50 17 0 50 25 0 0 9 0 % K
% Leu: 0 9 9 9 0 0 0 0 0 0 9 17 0 42 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 42 % M
% Asn: 0 59 0 42 0 0 9 9 0 0 0 0 17 0 0 % N
% Pro: 0 0 0 0 0 0 9 0 0 0 0 9 9 0 0 % P
% Gln: 0 0 0 9 0 9 9 0 0 9 0 0 9 0 0 % Q
% Arg: 0 0 0 17 9 42 9 9 0 9 0 0 0 0 0 % R
% Ser: 0 9 9 0 9 17 0 17 9 9 0 0 0 0 0 % S
% Thr: 0 0 9 0 42 0 0 0 0 9 17 9 42 17 9 % T
% Val: 0 0 0 0 0 9 0 0 9 0 0 0 17 9 9 % V
% Trp: 0 0 0 0 0 9 0 0 9 0 9 0 0 0 0 % W
% Tyr: 42 9 9 0 9 9 0 42 0 0 0 0 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _