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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EDC3
All Species:
25.15
Human Site:
Y258
Identified Species:
50.3
UniProt:
Q96F86
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96F86
NP_001135915.1
508
56078
Y258
L
E
S
E
P
I
V
Y
R
R
I
I
V
P
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001097687
287
31155
P68
E
L
K
I
L
E
I
P
G
P
G
G
N
Q
H
Dog
Lupus familis
XP_867080
508
56081
Y258
L
E
S
E
P
I
V
Y
R
R
I
T
V
P
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8K2D3
508
55939
Y258
L
E
S
E
P
I
V
Y
R
R
I
T
V
P
H
Rat
Rattus norvegicus
XP_001072079
506
55875
Y256
L
E
S
E
P
I
V
Y
R
R
I
T
V
P
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZLS2
506
56018
Y256
L
E
S
E
P
I
V
Y
R
R
I
V
V
P
Q
Frog
Xenopus laevis
Q5XH48
505
55557
Y255
L
E
S
E
P
I
V
Y
R
K
I
V
V
P
Q
Zebra Danio
Brachydanio rerio
Q502M5
507
54834
Y257
L
E
A
K
P
V
V
Y
R
Q
I
T
V
P
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI2
680
73397
L402
L
A
S
K
P
L
Q
L
R
Q
I
E
S
M
F
Honey Bee
Apis mellifera
XP_392618
616
68864
L373
I
V
S
E
P
T
D
L
R
Q
I
M
V
P
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787406
618
67525
G368
E
R
R
E
S
E
E
G
K
R
I
T
C
P
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39998
551
61322
M252
V
L
A
K
L
G
Q
M
I
I
S
Q
S
R
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
53.5
96.4
N.A.
95.6
95.8
N.A.
N.A.
88.3
75.1
68.9
N.A.
26.9
30.3
N.A.
35.2
Protein Similarity:
100
N.A.
55.3
98.2
N.A.
97.8
98
N.A.
N.A.
94
85.4
80.3
N.A.
45.2
47
N.A.
51.6
P-Site Identity:
100
N.A.
6.6
93.3
N.A.
93.3
93.3
N.A.
N.A.
86.6
80
60
N.A.
33.3
46.6
N.A.
26.6
P-Site Similarity:
100
N.A.
13.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
93.3
93.3
86.6
N.A.
53.3
73.3
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
39.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
17
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% C
% Asp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
9
% D
% Glu:
17
59
0
67
0
17
9
0
0
0
0
9
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% F
% Gly:
0
0
0
0
0
9
0
9
9
0
9
9
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
42
% H
% Ile:
9
0
0
9
0
50
9
0
9
9
84
9
0
0
0
% I
% Lys:
0
0
9
25
0
0
0
0
9
9
0
0
0
0
0
% K
% Leu:
67
17
0
0
17
9
0
17
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
9
0
0
0
9
0
9
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
9
% N
% Pro:
0
0
0
0
75
0
0
9
0
9
0
0
0
75
0
% P
% Gln:
0
0
0
0
0
0
17
0
0
25
0
9
0
9
25
% Q
% Arg:
0
9
9
0
0
0
0
0
75
50
0
0
0
9
0
% R
% Ser:
0
0
67
0
9
0
0
0
0
0
9
0
17
0
9
% S
% Thr:
0
0
0
0
0
9
0
0
0
0
0
42
0
0
0
% T
% Val:
9
9
0
0
0
9
59
0
0
0
0
17
67
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
59
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _