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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED8
All Species:
18.48
Human Site:
S200
Identified Species:
33.89
UniProt:
Q96G25
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96G25
NP_443109.2
268
29080
S200
N
W
R
P
S
G
S
S
G
P
G
Q
A
G
Q
Chimpanzee
Pan troglodytes
XP_001173582
268
29088
S200
N
W
R
P
S
G
S
S
G
P
G
Q
A
G
Q
Rhesus Macaque
Macaca mulatta
XP_001094002
268
28917
S200
N
W
R
P
S
G
S
S
G
P
G
Q
P
G
Q
Dog
Lupus familis
XP_853421
284
30931
S216
N
W
R
P
S
G
S
S
G
P
G
Q
P
G
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q9D7W5
268
29181
S200
N
W
R
P
S
G
S
S
G
P
G
Q
P
G
Q
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512637
318
34281
G243
N
W
R
P
A
V
A
G
G
P
G
Q
P
G
Q
Chicken
Gallus gallus
XP_422404
268
29296
G200
N
R
R
P
P
G
S
G
G
S
V
Q
S
G
Q
Frog
Xenopus laevis
Q5HZZ6
268
29516
G200
N
R
R
P
P
G
Q
G
G
P
M
A
P
G
Q
Zebra Danio
Brachydanio rerio
Q6NYT1
267
29384
P200
G
L
S
K
C
R
P
P
G
P
V
A
P
G
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZBT5
252
27930
A185
A
D
T
Q
L
L
V
A
A
V
G
M
G
K
G
Honey Bee
Apis mellifera
XP_623274
257
28425
G190
L
V
A
A
V
G
M
G
K
G
L
K
S
D
S
Nematode Worm
Caenorhab. elegans
Q9U1W2
297
33419
T227
P
S
S
A
P
M
T
T
A
P
S
S
T
G
P
Sea Urchin
Strong. purpuratus
XP_787301
200
22091
I133
P
D
S
S
K
L
N
I
T
T
S
S
P
S
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
89.5
89
N.A.
96.6
N.A.
N.A.
76
88.8
77.6
67.9
N.A.
44.7
44.4
21.2
38
Protein Similarity:
100
100
91.7
89.4
N.A.
97.3
N.A.
N.A.
78.9
92.9
86.1
80.2
N.A.
61.5
64.1
41.4
53.7
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
N.A.
N.A.
66.6
60
53.3
20
N.A.
6.6
6.6
13.3
0
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
N.A.
N.A.
80
66.6
53.3
20
N.A.
13.3
20
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
16
8
0
8
8
16
0
0
16
16
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
16
0
0
0
0
0
0
0
0
0
0
0
8
8
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
62
0
31
70
8
54
0
8
77
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
8
0
0
0
8
0
0
8
0
8
0
% K
% Leu:
8
8
0
0
8
16
0
0
0
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
8
8
0
0
0
8
8
0
0
0
% M
% Asn:
62
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
16
0
0
62
24
0
8
8
0
70
0
0
54
0
8
% P
% Gln:
0
0
0
8
0
0
8
0
0
0
0
54
0
0
62
% Q
% Arg:
0
16
62
0
0
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
24
8
39
0
47
39
0
8
16
16
16
8
8
% S
% Thr:
0
0
8
0
0
0
8
8
8
8
0
0
8
0
0
% T
% Val:
0
8
0
0
8
8
8
0
0
8
16
0
0
0
0
% V
% Trp:
0
47
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _