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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MED8
All Species:
22.42
Human Site:
S237
Identified Species:
41.11
UniProt:
Q96G25
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96G25
NP_443109.2
268
29080
S237
S
Q
Q
Q
P
M
L
S
G
V
Q
M
A
Q
A
Chimpanzee
Pan troglodytes
XP_001173582
268
29088
S237
S
Q
Q
Q
P
M
L
S
G
V
Q
M
A
Q
A
Rhesus Macaque
Macaca mulatta
XP_001094002
268
28917
S237
S
Q
Q
Q
P
M
L
S
G
V
Q
M
A
Q
A
Dog
Lupus familis
XP_853421
284
30931
S253
S
Q
Q
Q
P
L
L
S
G
V
Q
M
A
Q
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9D7W5
268
29181
S237
N
Q
Q
Q
P
M
L
S
G
V
Q
M
A
Q
A
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512637
318
34281
Q280
A
G
A
P
G
Q
Q
Q
Q
Q
Q
A
L
L
A
Chicken
Gallus gallus
XP_422404
268
29296
A237
A
Q
Q
Q
P
M
L
A
G
V
Q
M
A
Q
A
Frog
Xenopus laevis
Q5HZZ6
268
29516
A237
N
Q
Q
Q
Q
H
M
A
G
V
S
M
S
Q
G
Zebra Danio
Brachydanio rerio
Q6NYT1
267
29384
P237
H
Q
A
G
M
S
G
P
V
A
P
Q
Q
P
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZBT5
252
27930
S222
P
M
G
G
P
A
M
S
P
G
N
V
Q
Q
Q
Honey Bee
Apis mellifera
XP_623274
257
28425
S227
Q
Q
Q
T
P
G
Q
S
L
G
N
P
P
M
G
Nematode Worm
Caenorhab. elegans
Q9U1W2
297
33419
S264
S
G
G
Q
P
Q
T
S
Q
A
H
L
P
M
Y
Sea Urchin
Strong. purpuratus
XP_787301
200
22091
M170
M
S
N
M
G
A
Q
M
A
R
Q
G
D
Q
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
89.5
89
N.A.
96.6
N.A.
N.A.
76
88.8
77.6
67.9
N.A.
44.7
44.4
21.2
38
Protein Similarity:
100
100
91.7
89.4
N.A.
97.3
N.A.
N.A.
78.9
92.9
86.1
80.2
N.A.
61.5
64.1
41.4
53.7
P-Site Identity:
100
100
100
93.3
N.A.
93.3
N.A.
N.A.
13.3
86.6
46.6
6.6
N.A.
20
26.6
26.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
20
100
73.3
6.6
N.A.
33.3
26.6
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
16
0
0
16
0
16
8
16
0
8
47
0
54
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
16
16
16
16
8
8
0
54
16
0
8
0
0
24
% G
% His:
8
0
0
0
0
8
0
0
0
0
8
0
0
0
8
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
8
47
0
8
0
0
8
8
8
0
% L
% Met:
8
8
0
8
8
39
16
8
0
0
0
54
0
16
0
% M
% Asn:
16
0
8
0
0
0
0
0
0
0
16
0
0
0
0
% N
% Pro:
8
0
0
8
70
0
0
8
8
0
8
8
16
8
0
% P
% Gln:
8
70
62
62
8
16
24
8
16
8
62
8
16
70
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
39
8
0
0
0
8
0
62
0
0
8
0
8
0
0
% S
% Thr:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
8
54
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _