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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CENPN All Species: 8.79
Human Site: T172 Identified Species: 21.48
UniProt: Q96H22 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96H22 NP_001094094.1 339 39541 T172 S S M L R R N T P L L G Q A L
Chimpanzee Pan troglodytes XP_511126 339 39532 T172 S S M L R R N T P L L G Q A L
Rhesus Macaque Macaca mulatta XP_001111366 339 39508 T172 S S T L R R N T P L L G Q A L
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q9CZW2 337 39222 V172 S C H L K N T V P L L H Q A L
Rat Rattus norvegicus Q5U2W4 340 39441 V173 S C Y L K S T V P L L H Q A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508634 381 44302 I172 L S A N K S C I P L L C Q A L
Chicken Gallus gallus Q1T765 344 40326 L171 A S V L R S N L P L L C Q A M
Frog Xenopus laevis Q5XH29 348 39710 R170 T G L G K A C R P L M C Q A L
Zebra Danio Brachydanio rerio NP_001002341 345 39262 I171 N L M A K H K I F L C Q A L V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789578 334 38496 H170 V Y Y P H S R H L I V S V R K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 96.7 N.A. N.A. 72.8 71.4 N.A. 55.3 59 50.2 31.5 N.A. N.A. N.A. N.A. 26.2
Protein Similarity: 100 99.4 98.2 N.A. N.A. 87.3 85.5 N.A. 70.3 75.5 69.8 56.2 N.A. N.A. N.A. N.A. 47.2
P-Site Identity: 100 100 93.3 N.A. N.A. 53.3 53.3 N.A. 46.6 60 33.3 13.3 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 93.3 N.A. N.A. 60 60 N.A. 53.3 80 60 33.3 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 10 0 10 0 0 0 0 0 0 10 80 0 % A
% Cys: 0 20 0 0 0 0 20 0 0 0 10 30 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % F
% Gly: 0 10 0 10 0 0 0 0 0 0 0 30 0 0 0 % G
% His: 0 0 10 0 10 10 0 10 0 0 0 20 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 20 0 10 0 0 0 0 0 % I
% Lys: 0 0 0 0 50 0 10 0 0 0 0 0 0 0 10 % K
% Leu: 10 10 10 60 0 0 0 10 10 90 70 0 0 10 70 % L
% Met: 0 0 30 0 0 0 0 0 0 0 10 0 0 0 10 % M
% Asn: 10 0 0 10 0 10 40 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 10 0 0 0 0 80 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 10 80 0 0 % Q
% Arg: 0 0 0 0 40 30 10 10 0 0 0 0 0 10 0 % R
% Ser: 50 50 0 0 0 40 0 0 0 0 0 10 0 0 0 % S
% Thr: 10 0 10 0 0 0 20 30 0 0 0 0 0 0 0 % T
% Val: 10 0 10 0 0 0 0 20 0 0 10 0 10 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 20 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _