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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DIRAS2 All Species: 23.33
Human Site: S183 Identified Species: 34.22
UniProt: Q96HU8 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96HU8 NP_060064.2 199 22485 S183 L Q I D G K K S K Q Q K R K E
Chimpanzee Pan troglodytes XP_001142084 196 21944 N182 S L S Q G E E N S I K R I E P
Rhesus Macaque Macaca mulatta XP_001099006 198 22268 S182 L N I D G K R S G K Q K R T D
Dog Lupus familis XP_541313 208 23428 S192 L Q I D G K K S K Q Q K R K E
Cat Felis silvestris
Mouse Mus musculus Q5PR73 199 22479 S183 L Q I D G K K S K Q Q K R K E
Rat Rattus norvegicus Q62636 184 20779 K177 P V P G K A R K K S S C Q L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513649 198 22370 A182 L Q V D G K K A K Q Q K K K D
Chicken Gallus gallus XP_423026 199 22563 S183 L Q I D G K K S K Q Q K R K E
Frog Xenopus laevis Q7ZXH7 184 20815 R176 T P V P G K A R K K S T C H L
Zebra Danio Brachydanio rerio Q6TEN1 184 20809 R176 T P V T G K P R K K S T C Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P08645 184 20845 K177 E K K Q K K P K K S L C V L L
Honey Bee Apis mellifera XP_001121695 205 22930 N185 L Q P V Q S N N A I S L K E K
Nematode Worm Caenorhab. elegans P34443 207 23677 P192 E R P N G N S P K R N P F K D
Sea Urchin Strong. purpuratus XP_780973 198 22635 T182 L H L E T K K T K S Q K R R E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P13856 272 30372 S257 R T G I S A T S Q Q K K K K K
Red Bread Mold Neurospora crassa Q01387 229 25331 R192 V K Q L R K Q R Q Q G Q S T P
Conservation
Percent
Protein Identity: 100 86.4 78.3 93.2 N.A. 98.9 41.7 N.A. 82.4 93.4 41.7 41.7 N.A. 42.2 71.7 39.1 79.4
Protein Similarity: 100 89.9 90.4 94.7 N.A. 100 61.8 N.A. 91.9 96.9 61.8 61.3 N.A. 63.3 79.5 52.1 89.4
P-Site Identity: 100 6.6 60 100 N.A. 100 6.6 N.A. 73.3 100 20 20 N.A. 13.3 13.3 20 53.3
P-Site Similarity: 100 46.6 80 100 N.A. 100 20 N.A. 100 100 33.3 40 N.A. 20 40 46.6 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.9 36.6
Protein Similarity: N.A. N.A. N.A. N.A. 49.2 50.6
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 53.3 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 13 7 7 7 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 13 13 0 0 % C
% Asp: 0 0 0 38 0 0 0 0 0 0 0 0 0 0 19 % D
% Glu: 13 0 0 7 0 7 7 0 0 0 0 0 0 13 32 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % F
% Gly: 0 0 7 7 63 0 0 0 7 0 7 0 0 0 0 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 32 7 0 0 0 0 0 13 0 0 7 0 0 % I
% Lys: 0 13 7 0 13 69 38 13 69 19 13 50 19 44 13 % K
% Leu: 50 7 7 7 0 0 0 0 0 0 7 7 0 13 25 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 7 0 7 7 13 0 0 7 0 0 0 0 % N
% Pro: 7 13 19 7 0 0 13 7 0 0 0 7 0 0 13 % P
% Gln: 0 38 7 13 7 0 7 0 13 44 44 7 7 7 0 % Q
% Arg: 7 7 0 0 7 0 13 19 0 7 0 7 38 7 0 % R
% Ser: 7 0 7 0 7 7 7 38 7 19 25 0 7 0 0 % S
% Thr: 13 7 0 7 7 0 7 7 0 0 0 13 0 13 0 % T
% Val: 7 7 19 7 0 0 0 0 0 0 0 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _