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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SCLY All Species: 41.21
Human Site: S390 Identified Species: 69.74
UniProt: Q96I15 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96I15 NP_057594.3 445 48149 S390 S V G A A C H S D H G D Q P S
Chimpanzee Pan troglodytes XP_516185 456 49030 G401 I K Q Q L Q L G L A L P R P S
Rhesus Macaque Macaca mulatta XP_001085800 445 48195 S390 S V G A A C H S D H G D Q P S
Dog Lupus familis XP_534618 444 48534 S389 S V G A A C H S D H A D R P S
Cat Felis silvestris
Mouse Mus musculus Q9JLI6 432 47155 S377 S V G A S C H S N H E D R P S
Rat Rattus norvegicus Q68FT9 432 47237 S377 S V G A S C H S D H E D R P S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513711 443 48507 S386 S V G A A C H S D K G D Q P S
Chicken Gallus gallus NP_001132935 423 45535 S366 S V G A A C H S E K G D R P S
Frog Xenopus laevis Q66IQ6 426 46244 S369 S V G A A C H S D R G D S P S
Zebra Danio Brachydanio rerio NP_001103853 450 49170 S395 S V G A A C H S D R G D Q P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_495258 328 35781 K288 N E C S P I L K A C G I P F A
Sea Urchin Strong. purpuratus XP_788466 454 49588 S397 S V G A A C H S D T G D R P S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O49543 453 50277 T378 V S S G S A C T S A S L E P S
Baker's Yeast Sacchar. cerevisiae P25374 497 54449 T422 L S S G S A C T S A S L E P S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79.8 95.9 80.4 N.A. 78.4 77.9 N.A. 72.8 66.5 59.7 58.6 N.A. N.A. N.A. 32.8 54.8
Protein Similarity: 100 83.3 97.9 88.3 N.A. 88 87.4 N.A. 83.3 79 76.1 74.6 N.A. N.A. N.A. 46.9 70.2
P-Site Identity: 100 13.3 100 86.6 N.A. 73.3 80 N.A. 93.3 80 86.6 93.3 N.A. N.A. N.A. 6.6 86.6
P-Site Similarity: 100 20 100 93.3 N.A. 93.3 93.3 N.A. 93.3 93.3 86.6 93.3 N.A. N.A. N.A. 26.6 93.3
Percent
Protein Identity: N.A. N.A. N.A. 24.5 20.9 N.A.
Protein Similarity: N.A. N.A. N.A. 42.8 39.6 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 72 58 15 0 0 8 22 8 0 0 0 8 % A
% Cys: 0 0 8 0 0 72 15 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 58 0 0 72 0 0 0 % D
% Glu: 0 8 0 0 0 0 0 0 8 0 15 0 15 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 0 72 15 0 0 0 8 0 0 58 0 0 0 0 % G
% His: 0 0 0 0 0 0 72 0 0 36 0 0 0 0 0 % H
% Ile: 8 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 8 0 0 0 0 0 8 0 15 0 0 0 0 0 % K
% Leu: 8 0 0 0 8 0 15 0 8 0 8 15 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 8 0 0 0 0 0 0 8 8 93 0 % P
% Gln: 0 0 8 8 0 8 0 0 0 0 0 0 29 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 15 0 0 43 0 0 % R
% Ser: 72 15 15 8 29 0 0 72 15 0 15 0 8 0 93 % S
% Thr: 0 0 0 0 0 0 0 15 0 8 0 0 0 0 0 % T
% Val: 8 72 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _