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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SCLY All Species: 41.82
Human Site: S397 Identified Species: 70.77
UniProt: Q96I15 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96I15 NP_057594.3 445 48149 S397 S D H G D Q P S P V L L S Y G
Chimpanzee Pan troglodytes XP_516185 456 49030 S408 G L A L P R P S P V L L S Y G
Rhesus Macaque Macaca mulatta XP_001085800 445 48195 S397 S D H G D Q P S P V L L N C G
Dog Lupus familis XP_534618 444 48534 S396 S D H A D R P S P V L L S C G
Cat Felis silvestris
Mouse Mus musculus Q9JLI6 432 47155 S384 S N H E D R P S P V L L S C G
Rat Rattus norvegicus Q68FT9 432 47237 S384 S D H E D R P S P V L L S C G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513711 443 48507 S393 S D K G D Q P S S I L L N C G
Chicken Gallus gallus NP_001132935 423 45535 S373 S E K G D R P S L I L L S C G
Frog Xenopus laevis Q66IQ6 426 46244 S376 S D R G D S P S P V L L K S G
Zebra Danio Brachydanio rerio NP_001103853 450 49170 S402 S D R G D Q P S H I L L S C G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_495258 328 35781 A295 K A C G I P F A V A S K T V R
Sea Urchin Strong. purpuratus XP_788466 454 49588 S404 S D T G D R P S H I L L A I G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O49543 453 50277 S385 T S A S L E P S Y V L R A L G
Baker's Yeast Sacchar. cerevisiae P25374 497 54449 S429 T S A S L E P S Y V L H A L G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79.8 95.9 80.4 N.A. 78.4 77.9 N.A. 72.8 66.5 59.7 58.6 N.A. N.A. N.A. 32.8 54.8
Protein Similarity: 100 83.3 97.9 88.3 N.A. 88 87.4 N.A. 83.3 79 76.1 74.6 N.A. N.A. N.A. 46.9 70.2
P-Site Identity: 100 60 86.6 80 N.A. 73.3 80 N.A. 66.6 60 73.3 73.3 N.A. N.A. N.A. 6.6 60
P-Site Similarity: 100 66.6 93.3 86.6 N.A. 86.6 86.6 N.A. 80 80 73.3 80 N.A. N.A. N.A. 20 80
Percent
Protein Identity: N.A. N.A. N.A. 24.5 20.9 N.A.
Protein Similarity: N.A. N.A. N.A. 42.8 39.6 N.A.
P-Site Identity: N.A. N.A. N.A. 33.3 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 22 8 0 0 0 8 0 8 0 0 22 0 0 % A
% Cys: 0 0 8 0 0 0 0 0 0 0 0 0 0 50 0 % C
% Asp: 0 58 0 0 72 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 8 0 15 0 15 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 58 0 0 0 0 0 0 0 0 0 0 93 % G
% His: 0 0 36 0 0 0 0 0 15 0 0 8 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 29 0 0 0 8 0 % I
% Lys: 8 0 15 0 0 0 0 0 0 0 0 8 8 0 0 % K
% Leu: 0 8 0 8 15 0 0 0 8 0 93 79 0 15 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 0 0 0 0 0 0 0 15 0 0 % N
% Pro: 0 0 0 0 8 8 93 0 50 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 15 0 0 43 0 0 0 0 0 8 0 0 8 % R
% Ser: 72 15 0 15 0 8 0 93 8 0 8 0 50 8 0 % S
% Thr: 15 0 8 0 0 0 0 0 0 0 0 0 8 0 0 % T
% Val: 0 0 0 0 0 0 0 0 8 65 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 15 0 0 0 0 15 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _