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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HPDL All Species: 33.94
Human Site: Y288 Identified Species: 62.22
UniProt: Q96IR7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96IR7 NP_116145.1 371 39386 Y288 L A P P G A Y Y Q Q P G K E R
Chimpanzee Pan troglodytes XP_524567 371 39368 Y288 L A P P G A Y Y Q Q P G K E R
Rhesus Macaque Macaca mulatta XP_001100445 381 40428 Y288 L A P P G A Y Y Q Q P G K E R
Dog Lupus familis XP_539633 399 42418 Y288 L A P P E A Y Y Q Q P G K E R
Cat Felis silvestris
Mouse Mus musculus Q8K248 371 39891 Y288 L T P P E A Y Y Q Q P G K E E
Rat Rattus norvegicus Q5XIH9 371 40014 Y288 L T P P E A Y Y Q Q P G K E E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_426651 387 41725 Y290 F T P P A A Y Y S Q G G K E E
Frog Xenopus laevis NP_001085702 391 43668 Y294 A I Q P S S Y Y S E T K K Q K
Zebra Danio Brachydanio rerio Q6TGZ5 397 45192 Y297 L S A P D N Y Y E S L R E K L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q22633 393 44365 Y297 L S I P S S Y Y D N L K E R L
Sea Urchin Strong. purpuratus XP_001182551 270 30553 F212 H K Y L M Q V F T R P F F D R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93836 445 48797 Y342 M P S P P P T Y Y Q N L K K R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q872T7 412 46010 Y325 I N V P S T Y Y D T I R Q R L
Conservation
Percent
Protein Identity: 100 99.7 92.9 78.4 N.A. 78.7 79.5 N.A. N.A. 48.5 40.1 27.9 N.A. N.A. N.A. 26.7 30.7
Protein Similarity: 100 100 94.7 83.7 N.A. 85.1 85.7 N.A. N.A. 62.7 57.2 45.8 N.A. N.A. N.A. 43.2 46
P-Site Identity: 100 100 100 93.3 N.A. 80 80 N.A. N.A. 60 26.6 26.6 N.A. N.A. N.A. 26.6 13.3
P-Site Similarity: 100 100 100 93.3 N.A. 80 80 N.A. N.A. 60 53.3 53.3 N.A. N.A. N.A. 46.6 33.3
Percent
Protein Identity: N.A. N.A. N.A. 23.1 N.A. 20.1
Protein Similarity: N.A. N.A. N.A. 37.3 N.A. 38.8
P-Site Identity: N.A. N.A. N.A. 33.3 N.A. 20
P-Site Similarity: N.A. N.A. N.A. 46.6 N.A. 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 31 8 0 8 54 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 0 0 16 0 0 0 0 8 0 % D
% Glu: 0 0 0 0 24 0 0 0 8 8 0 0 16 54 24 % E
% Phe: 8 0 0 0 0 0 0 8 0 0 0 8 8 0 0 % F
% Gly: 0 0 0 0 24 0 0 0 0 0 8 54 0 0 0 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 8 8 0 0 0 0 0 0 0 8 0 0 0 0 % I
% Lys: 0 8 0 0 0 0 0 0 0 0 0 16 70 16 8 % K
% Leu: 62 0 0 8 0 0 0 0 0 0 16 8 0 0 24 % L
% Met: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 0 0 0 8 0 0 0 8 8 0 0 0 0 % N
% Pro: 0 8 54 93 8 8 0 0 0 0 54 0 0 0 0 % P
% Gln: 0 0 8 0 0 8 0 0 47 62 0 0 8 8 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 8 0 16 0 16 47 % R
% Ser: 0 16 8 0 24 16 0 0 16 8 0 0 0 0 0 % S
% Thr: 0 24 0 0 0 8 8 0 8 8 8 0 0 0 0 % T
% Val: 0 0 8 0 0 0 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 85 93 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _