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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NGLY1 All Species: 32.42
Human Site: S572 Identified Species: 47.56
UniProt: Q96IV0 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96IV0 NP_001138765.1 654 74390 S572 D S I S I R T S S Q T F Q T G
Chimpanzee Pan troglodytes XP_516333 835 93255 S753 D S I S I R T S S Q T F Q T G
Rhesus Macaque Macaca mulatta XP_001093251 654 74564 T572 D S I S I R T T S Q T F Q T G
Dog Lupus familis XP_534241 2041 231068 P1599 N D L K R K S P S D L W K E D
Cat Felis silvestris
Mouse Mus musculus Q9JI78 651 74257 S569 D T V S I R T S S Q S F E S G
Rat Rattus norvegicus Q5XI55 651 74658 S569 D N V S I R T S S Q S F E T G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507250 647 73725 S565 D N I S V R T S S Q T F H S G
Chicken Gallus gallus Q5ZJM3 651 73884 S569 D N I S I R T S S Q T F H S G
Frog Xenopus laevis NP_001116357 635 72527 S554 E S I S V R T S S Q T F H S G
Zebra Danio Brachydanio rerio Q503I8 644 72470 F562 K S A S V R V F S Q T F H S G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KRR5 631 73298 K551 A W T F D F S K T N L K V K S
Honey Bee Apis mellifera XP_392561 589 68873 S509 C R S T T A I S G K I R W C F
Nematode Worm Caenorhab. elegans Q9TW67 606 69129 F526 R M A G I Q K F E K G K A M A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FGY9 721 82428 T622 G C W I V Y K T L Y N Q M H Q
Baker's Yeast Sacchar. cerevisiae Q02890 363 42466 Q283 Q N E L P R D Q I K E E D L K
Red Bread Mold Neurospora crassa Q7SI01 382 43903 R302 P D G E T R L R L Y R E D V A
Conservation
Percent
Protein Identity: 100 72.8 96.9 22.5 N.A. 84.5 84.4 N.A. 70.6 68.8 64.2 57.1 N.A. 32.8 35.1 31.3 N.A.
Protein Similarity: 100 74.2 98.9 27.3 N.A. 91.4 90.3 N.A. 81 81.3 78.1 72.6 N.A. 53.2 53 49 N.A.
P-Site Identity: 100 100 93.3 6.6 N.A. 66.6 73.3 N.A. 73.3 80 73.3 53.3 N.A. 0 6.6 6.6 N.A.
P-Site Similarity: 100 100 100 46.6 N.A. 100 100 N.A. 93.3 93.3 93.3 66.6 N.A. 13.3 20 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 29.9 25.9 23.2
Protein Similarity: N.A. N.A. N.A. 46.6 37.7 36.3
P-Site Identity: N.A. N.A. N.A. 0 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. 13.3 20 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 13 0 0 7 0 0 0 0 0 0 7 0 13 % A
% Cys: 7 7 0 0 0 0 0 0 0 0 0 0 0 7 0 % C
% Asp: 44 13 0 0 7 0 7 0 0 7 0 0 13 0 7 % D
% Glu: 7 0 7 7 0 0 0 0 7 0 7 13 13 7 0 % E
% Phe: 0 0 0 7 0 7 0 13 0 0 0 57 0 0 7 % F
% Gly: 7 0 7 7 0 0 0 0 7 0 7 0 0 0 57 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 25 7 0 % H
% Ile: 0 0 38 7 44 0 7 0 7 0 7 0 0 0 0 % I
% Lys: 7 0 0 7 0 7 13 7 0 19 0 13 7 7 7 % K
% Leu: 0 0 7 7 0 0 7 0 13 0 13 0 0 7 0 % L
% Met: 0 7 0 0 0 0 0 0 0 0 0 0 7 7 0 % M
% Asn: 7 25 0 0 0 0 0 0 0 7 7 0 0 0 0 % N
% Pro: 7 0 0 0 7 0 0 7 0 0 0 0 0 0 0 % P
% Gln: 7 0 0 0 0 7 0 7 0 57 0 7 19 0 7 % Q
% Arg: 7 7 0 0 7 69 0 7 0 0 7 7 0 0 0 % R
% Ser: 0 32 7 57 0 0 13 50 63 0 13 0 0 32 7 % S
% Thr: 0 7 7 7 13 0 50 13 7 0 44 0 0 25 0 % T
% Val: 0 0 13 0 25 0 7 0 0 0 0 0 7 7 0 % V
% Trp: 0 7 7 0 0 0 0 0 0 0 0 7 7 0 0 % W
% Tyr: 0 0 0 0 0 7 0 0 0 13 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _