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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ITCH All Species: 0.61
Human Site: S569 Identified Species: 1.21
UniProt: Q96J02 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.36
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96J02 NP_113671.3 903 102803 S569 F Q Q I M S F S P Q D L R R R
Chimpanzee Pan troglodytes XP_001135661 927 105765 K593 F Q Q I M A L K P Y D L R R R
Rhesus Macaque Macaca mulatta XP_001083053 927 105532 K593 F Q Q I M A L K P Y D L R R R
Dog Lupus familis XP_851460 862 98826 V551 E G L D Y G G V A R E W F F L
Cat Felis silvestris
Mouse Mus musculus Q8C863 864 98975 V553 E G L D Y G G V A R E W F F L
Rat Rattus norvegicus Q62940 887 102376 K556 V K R A D F L K A R L W I E F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506950 1107 125075 K773 F Q Q I M A L K P Y D L R R R
Chicken Gallus gallus XP_417330 878 99980 L552 P Q D L R R R L W V I F P G E
Frog Xenopus laevis Q2TAS2 751 86306 G458 D M L N P Y Y G L F Q Y S R D
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 G472 E M L N P Y Y G L F Q Y S R D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9Y0H4 949 107948 P615 Y H Q I M R L P A Y E L R R R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 Y516 H E M F N P F Y C L F E Y S A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 59 59 93 N.A. 91.6 30.7 N.A. 49.2 78.1 35.8 36.2 N.A. 49.6 N.A. N.A. N.A.
Protein Similarity: 100 72.1 71.7 94.2 N.A. 93.6 47.9 N.A. 62.4 84.5 52.4 52 N.A. 64 N.A. N.A. N.A.
P-Site Identity: 100 73.3 73.3 0 N.A. 0 0 N.A. 73.3 6.6 6.6 6.6 N.A. 46.6 N.A. N.A. N.A.
P-Site Similarity: 100 80 80 13.3 N.A. 13.3 20 N.A. 80 13.3 13.3 13.3 N.A. 60 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 34.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 25 0 0 34 0 0 0 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % C
% Asp: 9 0 9 17 9 0 0 0 0 0 34 0 0 0 17 % D
% Glu: 25 9 0 0 0 0 0 0 0 0 25 9 0 9 9 % E
% Phe: 34 0 0 9 0 9 17 0 0 17 9 9 17 17 9 % F
% Gly: 0 17 0 0 0 17 17 17 0 0 0 0 0 9 0 % G
% His: 9 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 42 0 0 0 0 0 0 9 0 9 0 0 % I
% Lys: 0 9 0 0 0 0 0 34 0 0 0 0 0 0 0 % K
% Leu: 0 0 34 9 0 0 42 9 17 9 9 42 0 0 17 % L
% Met: 0 17 9 0 42 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 17 9 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 9 0 0 0 17 9 0 9 34 0 0 0 9 0 0 % P
% Gln: 0 42 42 0 0 0 0 0 0 9 17 0 0 0 0 % Q
% Arg: 0 0 9 0 9 17 9 0 0 25 0 0 42 59 42 % R
% Ser: 0 0 0 0 0 9 0 9 0 0 0 0 17 9 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 9 0 0 0 0 0 0 17 0 9 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 9 0 0 25 0 0 0 % W
% Tyr: 9 0 0 0 17 17 17 9 0 34 0 17 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _