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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ITCH
All Species:
17.27
Human Site:
Y376
Identified Species:
34.55
UniProt:
Q96J02
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96J02
NP_113671.3
903
102803
Y376
D
N
M
G
R
I
Y
Y
V
D
H
F
T
R
T
Chimpanzee
Pan troglodytes
XP_001135661
927
105765
Y399
D
D
R
R
R
V
Y
Y
V
D
H
N
T
R
T
Rhesus Macaque
Macaca mulatta
XP_001083053
927
105532
Y399
D
D
R
G
R
V
Y
Y
V
D
H
N
T
R
T
Dog
Lupus familis
XP_851460
862
98826
Q365
Q
W
Q
L
Q
R
S
Q
L
Q
G
A
M
Q
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8C863
864
98975
S366
E
Q
W
Q
L
Q
R
S
Q
L
Q
G
A
M
Q
Rat
Rattus norvegicus
Q62940
887
102376
Q369
Y
G
N
P
A
T
S
Q
P
V
T
S
S
N
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506950
1107
125075
Y584
D
D
R
G
R
V
Y
Y
V
D
H
N
T
R
T
Chicken
Gallus gallus
XP_417330
878
99980
T366
T
T
T
W
Q
R
P
T
L
E
S
V
R
N
Y
Frog
Xenopus laevis
Q2TAS2
751
86306
T272
G
Q
V
Y
F
L
H
T
Q
T
G
V
S
T
W
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
R286
W
H
D
P
R
V
P
R
D
L
S
N
V
N
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y0H4
949
107948
Y413
D
G
R
G
R
V
Y
Y
V
D
H
N
T
R
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
L330
T
G
G
T
T
S
G
L
G
E
L
P
S
G
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59
59
93
N.A.
91.6
30.7
N.A.
49.2
78.1
35.8
36.2
N.A.
49.6
N.A.
N.A.
N.A.
Protein Similarity:
100
72.1
71.7
94.2
N.A.
93.6
47.9
N.A.
62.4
84.5
52.4
52
N.A.
64
N.A.
N.A.
N.A.
P-Site Identity:
100
66.6
73.3
0
N.A.
0
0
N.A.
73.3
0
0
6.6
N.A.
66.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
80
86.6
20
N.A.
6.6
6.6
N.A.
86.6
20
26.6
20
N.A.
73.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
34.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
50.9
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
0
0
0
0
9
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% C
% Asp:
42
25
9
0
0
0
0
0
9
42
0
0
0
0
0
% D
% Glu:
9
0
0
0
0
0
0
0
0
17
0
0
0
0
0
% E
% Phe:
0
0
0
0
9
0
0
0
0
0
0
9
0
0
0
% F
% Gly:
9
25
9
34
0
0
9
0
9
0
17
9
0
9
0
% G
% His:
0
9
0
0
0
0
9
0
0
0
42
0
0
0
9
% H
% Ile:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% K
% Leu:
0
0
0
9
9
9
0
9
17
17
9
0
0
0
0
% L
% Met:
0
0
9
0
0
0
0
0
0
0
0
0
9
9
0
% M
% Asn:
0
9
9
0
0
0
0
0
0
0
0
42
0
25
0
% N
% Pro:
0
0
0
17
0
0
17
0
9
0
0
9
0
0
0
% P
% Gln:
9
17
9
9
17
9
0
17
17
9
9
0
0
9
17
% Q
% Arg:
0
0
34
9
50
17
9
9
0
0
0
0
9
42
0
% R
% Ser:
0
0
0
0
0
9
17
9
0
0
17
9
25
0
0
% S
% Thr:
17
9
9
9
9
9
0
17
0
9
9
0
42
9
34
% T
% Val:
0
0
9
0
0
42
0
0
42
9
0
17
9
0
0
% V
% Trp:
9
9
9
9
0
0
0
0
0
0
0
0
0
0
17
% W
% Tyr:
9
0
0
9
0
0
42
42
0
0
0
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _