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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEKHA8
All Species:
13.94
Human Site:
S253
Identified Species:
43.81
UniProt:
Q96JA3
Number Species:
7
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96JA3
NP_116028.1
519
58306
S253
K
S
A
E
I
D
C
S
I
S
S
E
E
N
T
Chimpanzee
Pan troglodytes
XP_527709
519
58225
S253
K
S
A
E
I
D
C
S
I
S
S
E
E
N
T
Rhesus Macaque
Macaca mulatta
XP_001086395
519
58066
S253
K
S
A
G
I
D
C
S
I
S
S
E
E
N
T
Dog
Lupus familis
XP_545547
293
32986
T52
K
V
H
S
A
D
N
T
R
M
E
L
I
I
P
Cat
Felis silvestris
Mouse
Mus musculus
Q80W71
519
57943
S253
K
S
T
E
V
D
C
S
I
S
S
E
E
N
T
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_418736
519
58539
D253
E
T
N
E
R
S
S
D
V
S
V
E
D
H
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q5U3N0
549
61436
Q257
E
S
G
L
M
E
D
Q
N
D
L
I
E
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001197978
511
56706
A252
S
Q
E
G
V
Q
A
A
I
A
S
T
P
N
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
98
29
N.A.
92
N.A.
N.A.
N.A.
73.5
N.A.
58.6
N.A.
N.A.
N.A.
N.A.
38.1
Protein Similarity:
100
99.6
99
41.4
N.A.
96.3
N.A.
N.A.
N.A.
83.4
N.A.
71.4
N.A.
N.A.
N.A.
N.A.
55.6
P-Site Identity:
100
100
93.3
13.3
N.A.
86.6
N.A.
N.A.
N.A.
20
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
20
P-Site Similarity:
100
100
93.3
20
N.A.
93.3
N.A.
N.A.
N.A.
53.3
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
38
0
13
0
13
13
0
13
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
50
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
63
13
13
0
13
0
0
13
0
0
% D
% Glu:
25
0
13
50
0
13
0
0
0
0
13
63
63
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
13
25
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
13
0
0
0
0
0
0
0
0
0
0
13
0
% H
% Ile:
0
0
0
0
38
0
0
0
63
0
0
13
13
13
13
% I
% Lys:
63
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
13
0
0
0
0
0
0
13
13
0
0
0
% L
% Met:
0
0
0
0
13
0
0
0
0
13
0
0
0
0
0
% M
% Asn:
0
0
13
0
0
0
13
0
13
0
0
0
0
63
25
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
13
13
13
% P
% Gln:
0
13
0
0
0
13
0
13
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
13
0
0
0
13
0
0
0
0
0
0
% R
% Ser:
13
63
0
13
0
13
13
50
0
63
63
0
0
0
0
% S
% Thr:
0
13
13
0
0
0
0
13
0
0
0
13
0
0
50
% T
% Val:
0
13
0
0
25
0
0
0
13
0
13
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _