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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COG3 All Species: 23.33
Human Site: S511 Identified Species: 42.78
UniProt: Q96JB2 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96JB2 NP_113619.1 828 94096 S511 D E Q K K V P S E A S F S D V
Chimpanzee Pan troglodytes XP_001158886 790 89707 G484 T G Y K P A P G D L A Y P D K
Rhesus Macaque Macaca mulatta XP_001096875 828 94056 S511 D E Q K K V P S E A S F S D V
Dog Lupus familis XP_848489 830 94828 S513 D E Q K K V P S E A S F S D V
Cat Felis silvestris
Mouse Mus musculus Q8CI04 820 93264 S503 D E Q K K A P S E A S F S D V
Rat Rattus norvegicus NP_001012157 828 94228 S511 D E Q K K T P S E A S F S D V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_417041 835 94848 S508 E E Q K K L P S E A S F S D V
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001137512 820 93798 E504 I A Q S L K E E Q M K L N S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q961G1 905 101221 A499 A L S L Q E P A P L R R S D S
Honey Bee Apis mellifera XP_393867 799 92557 M477 E E S R Q T K M K K I S I S S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001196648 781 87158 L483 L N Q S G S A L M S G Q T T P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_177485 784 88591 S473 E I A N Y T P S D E D L D Y P
Baker's Yeast Sacchar. cerevisiae P40094 801 92526 D488 T T S D D N P D P L L E S Y L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.2 98.9 95 N.A. 94.9 96.2 N.A. N.A. 86.4 N.A. 77 N.A. 40.2 41.5 N.A. 47.5
Protein Similarity: 100 95.4 99.7 97.1 N.A. 96.9 98.1 N.A. N.A. 92.5 N.A. 87 N.A. 56.4 60.5 N.A. 63.1
P-Site Identity: 100 20 100 100 N.A. 93.3 93.3 N.A. N.A. 86.6 N.A. 6.6 N.A. 20 6.6 N.A. 6.6
P-Site Similarity: 100 40 100 100 N.A. 93.3 93.3 N.A. N.A. 100 N.A. 20 N.A. 33.3 33.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. 35.7 21.6 N.A.
Protein Similarity: N.A. N.A. N.A. 54.8 43 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 8 0 0 16 8 8 0 47 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 39 0 0 8 8 0 0 8 16 0 8 0 8 62 0 % D
% Glu: 24 54 0 0 0 8 8 8 47 8 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 47 0 0 0 % F
% Gly: 0 8 0 0 8 0 0 8 0 0 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 8 8 0 0 0 0 0 0 0 0 8 0 8 0 0 % I
% Lys: 0 0 0 54 47 8 8 0 8 8 8 0 0 0 8 % K
% Leu: 8 8 0 8 8 8 0 8 0 24 8 16 0 0 8 % L
% Met: 0 0 0 0 0 0 0 8 8 8 0 0 0 0 0 % M
% Asn: 0 8 0 8 0 8 0 0 0 0 0 0 8 0 0 % N
% Pro: 0 0 0 0 8 0 77 0 16 0 0 0 8 0 16 % P
% Gln: 0 0 62 0 16 0 0 0 8 0 0 8 0 0 0 % Q
% Arg: 0 0 0 8 0 0 0 0 0 0 8 8 0 0 0 % R
% Ser: 0 0 24 16 0 8 0 54 0 8 47 8 62 16 24 % S
% Thr: 16 8 0 0 0 24 0 0 0 0 0 0 8 8 0 % T
% Val: 0 0 0 0 0 24 0 0 0 0 0 0 0 0 47 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 8 0 0 0 0 0 0 8 0 16 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _