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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MARK4 All Species: 35.15
Human Site: S218 Identified Species: 70.3
UniProt: Q96L34 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96L34 NP_113605.2 752 82520 S218 K L D T F C G S P P Y A A P E
Chimpanzee Pan troglodytes XP_512745 736 81102 S203 K L D T F C G S P P Y A A P E
Rhesus Macaque Macaca mulatta XP_001105523 666 73735 L182 E V R I M K G L N H P N I V K
Dog Lupus familis XP_541564 690 76525 S205 K L D T F C G S P P Y A A P E
Cat Felis silvestris
Mouse Mus musculus Q8CIP4 752 82625 S218 K L D T F C G S P P Y A A P E
Rat Rattus norvegicus Q8VHF0 797 88733 S215 K L D T F C G S P P Y A A P E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508081 736 82480 S207 K L D T F C G S P P Y A A P E
Chicken Gallus gallus Q9IA88 798 88848 S185 P L S T W C G S P P Y A A P E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 S218 L L K T W C G S P P Y A A P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 S329 K L D T F C G S P P Y A A P E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 I28 K L G K T L G I G S F G K V K
Baker's Yeast Sacchar. cerevisiae P06782 633 72027 M149 Y I V Q R D K M S E Q E A R R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.8 75.8 88.4 N.A. 97.6 60.4 N.A. 64.4 32.4 N.A. 29.3 N.A. N.A. N.A. 34.8 N.A.
Protein Similarity: 100 94.4 77.9 89.3 N.A. 98.9 73.5 N.A. 77.3 50 N.A. 41.2 N.A. N.A. N.A. 46.9 N.A.
P-Site Identity: 100 100 6.6 100 N.A. 100 100 N.A. 100 80 N.A. 80 N.A. N.A. N.A. 100 N.A.
P-Site Similarity: 100 100 26.6 100 N.A. 100 100 N.A. 100 86.6 N.A. 86.6 N.A. N.A. N.A. 100 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27.5 27.7 N.A.
Protein Similarity: N.A. N.A. N.A. 43.8 44.6 N.A.
P-Site Identity: N.A. N.A. N.A. 20 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 75 84 0 0 % A
% Cys: 0 0 0 0 0 75 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 59 0 0 9 0 0 0 0 0 0 0 0 0 % D
% Glu: 9 0 0 0 0 0 0 0 0 9 0 9 0 0 75 % E
% Phe: 0 0 0 0 59 0 0 0 0 0 9 0 0 0 0 % F
% Gly: 0 0 9 0 0 0 92 0 9 0 0 9 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % H
% Ile: 0 9 0 9 0 0 0 9 0 0 0 0 9 0 0 % I
% Lys: 67 0 9 9 0 9 9 0 0 0 0 0 9 0 17 % K
% Leu: 9 84 0 0 0 9 0 9 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 9 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 9 0 0 9 0 0 0 % N
% Pro: 9 0 0 0 0 0 0 0 75 75 9 0 0 75 0 % P
% Gln: 0 0 0 9 0 0 0 0 0 0 9 0 0 0 0 % Q
% Arg: 0 0 9 0 9 0 0 0 0 0 0 0 0 9 9 % R
% Ser: 0 0 9 0 0 0 0 75 9 9 0 0 0 0 0 % S
% Thr: 0 0 0 75 9 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 9 9 0 0 0 0 0 0 0 0 0 0 17 0 % V
% Trp: 0 0 0 0 17 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 0 0 0 0 0 0 0 0 75 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _