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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DHRS1
All Species:
22.73
Human Site:
Y275
Identified Species:
50
UniProt:
Q96LJ7
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96LJ7
NP_001129522.1
313
33909
Y275
D
G
R
P
V
Q
D
Y
L
S
L
S
S
V
L
Chimpanzee
Pan troglodytes
XP_001169595
313
33804
Y275
D
G
R
P
V
Q
D
Y
L
S
L
S
S
V
L
Rhesus Macaque
Macaca mulatta
XP_001113707
313
34036
Y275
D
G
R
P
V
Q
D
Y
L
S
L
S
S
V
L
Dog
Lupus familis
XP_537393
296
32202
Y258
D
G
R
P
I
Q
D
Y
L
S
L
S
S
V
L
Cat
Felis silvestris
Mouse
Mus musculus
Q99L04
313
33987
Y275
D
G
R
P
V
K
D
Y
F
S
L
G
Y
A
L
Rat
Rattus norvegicus
Q4V8F9
524
58325
S487
E
D
F
V
K
M
F
S
G
K
L
K
P
T
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520394
294
31581
A255
F
A
D
T
T
A
D
A
R
A
D
R
V
S
P
Chicken
Gallus gallus
Q8JIS3
246
26149
G209
M
I
N
R
I
P
L
G
K
F
A
E
V
D
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001002205
310
33871
Y272
D
G
R
S
I
V
D
Y
T
S
L
K
F
A
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21929
251
27201
K214
M
L
D
R
M
P
I
K
R
F
A
E
V
D
E
Sea Urchin
Strong. purpuratus
XP_797581
322
34924
Y285
D
G
H
R
P
M
N
Y
R
Q
L
K
A
L
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
91.6
96.4
77.9
N.A.
82.7
20.2
N.A.
38.6
23.9
N.A.
58.4
N.A.
N.A.
N.A.
22
50.6
Protein Similarity:
100
93.9
98
84.9
N.A.
91
32.2
N.A.
51.4
40.8
N.A.
77
N.A.
N.A.
N.A.
38
69.8
P-Site Identity:
100
100
100
93.3
N.A.
66.6
6.6
N.A.
6.6
0
N.A.
46.6
N.A.
N.A.
N.A.
0
26.6
P-Site Similarity:
100
100
100
100
N.A.
73.3
20
N.A.
13.3
6.6
N.A.
60
N.A.
N.A.
N.A.
6.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
10
0
10
0
10
19
0
10
19
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
64
10
19
0
0
0
64
0
0
0
10
0
0
19
10
% D
% Glu:
10
0
0
0
0
0
0
0
0
0
0
19
0
0
10
% E
% Phe:
10
0
10
0
0
0
10
0
10
19
0
0
10
0
0
% F
% Gly:
0
64
0
0
0
0
0
10
10
0
0
10
0
0
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
10
0
0
28
0
10
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
0
0
10
10
0
10
10
10
0
28
0
0
0
% K
% Leu:
0
10
0
0
0
0
10
0
37
0
73
0
0
10
46
% L
% Met:
19
0
0
0
10
19
0
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
10
0
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
46
10
19
0
0
0
0
0
0
10
0
10
% P
% Gln:
0
0
0
0
0
37
0
0
0
10
0
0
0
0
0
% Q
% Arg:
0
0
55
28
0
0
0
0
28
0
0
10
0
0
0
% R
% Ser:
0
0
0
10
0
0
0
10
0
55
0
37
37
10
0
% S
% Thr:
0
0
0
10
10
0
0
0
10
0
0
0
0
10
0
% T
% Val:
0
0
0
10
37
10
0
0
0
0
0
0
28
37
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
64
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _