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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HYLS1 All Species: 22.16
Human Site: S299 Identified Species: 54.17
UniProt: Q96M11 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96M11 NP_001128265.1 299 34359 S299 L P F P L S P S _ _ _ _ _ _ _
Chimpanzee Pan troglodytes XP_508880 298 34223 S298 L P F P L S P S _ _ _ _ _ _ _
Rhesus Macaque Macaca mulatta XP_001111926 299 34413 S299 L P F P L S P S _ _ _ _ _ _ _
Dog Lupus familis XP_852042 300 34499 S300 L P F P L F P S _ _ _ _ _ _ _
Cat Felis silvestris
Mouse Mus musculus Q9CXX0 307 35123 S307 L P F P L S P S _ _ _ _ _ _ _
Rat Rattus norvegicus XP_001056376 313 35709 S313 L P F P L S P S _ _ _ _ _ _ _
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519328 236 25944
Chicken Gallus gallus XP_001231543 277 30879 L277 I P R K S A P L _ _ _ _ _ _ _
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_504840 274 32164
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SUG3 353 39612 Q352 K K R A L A D Q Y _ _ _ _ _ _
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.3 88 N.A. 78.1 78.9 N.A. 20.7 38.1 N.A. N.A. N.A. N.A. N.A. 20.7 N.A.
Protein Similarity: 100 99.6 98.3 93 N.A. 82.4 84.3 N.A. 35.4 51.1 N.A. N.A. N.A. N.A. N.A. 35.4 N.A.
P-Site Identity: 100 100 100 87.5 N.A. 100 100 N.A. 0 25 N.A. N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 100 100 87.5 N.A. 100 100 N.A. 0 50 N.A. N.A. N.A. N.A. N.A. 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.8 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 35.9 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 11.1 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 10 0 20 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 60 0 0 10 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 10 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 60 0 0 0 70 0 0 10 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 70 0 60 0 0 70 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % Q
% Arg: 0 0 20 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 10 50 0 60 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 70 80 80 80 80 80 80 % _