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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
C12orf66
All Species:
23.03
Human Site:
S421
Identified Species:
56.3
UniProt:
Q96MD2
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96MD2
NP_689653.3
445
50415
S421
E
R
D
S
H
F
I
S
F
L
N
E
V
S
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116875
445
50376
S421
E
R
D
S
H
F
I
S
F
L
N
E
L
S
L
Dog
Lupus familis
XP_531657
445
50413
S421
E
R
D
S
H
F
I
S
F
L
N
E
L
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q6P1I3
445
50237
S421
E
R
D
S
H
F
I
S
F
L
N
E
L
S
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521346
418
46566
F395
R
D
S
H
F
V
S
F
L
H
E
L
S
H
T
Chicken
Gallus gallus
XP_416063
446
50573
S422
E
R
D
S
H
F
I
S
F
L
N
E
I
S
H
Frog
Xenopus laevis
Q6IR80
442
50506
S418
E
R
D
S
H
F
T
S
F
L
N
E
L
S
Q
Zebra Danio
Brachydanio rerio
Q1L8F9
449
51149
V424
S
E
R
D
S
Y
I
V
A
F
L
Q
E
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_624797
405
46699
S382
T
L
V
T
V
F
E
S
G
K
Q
K
D
K
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_797380
335
37612
H312
N
F
Q
G
L
G
Y
H
F
P
S
A
L
T
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.8
96.8
N.A.
94.3
N.A.
N.A.
69.6
93
81.8
74.8
N.A.
N.A.
32.1
N.A.
30.1
Protein Similarity:
100
N.A.
100
98.6
N.A.
96.4
N.A.
N.A.
80.6
97
90.5
87.9
N.A.
N.A.
54.1
N.A.
45.8
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
93.3
N.A.
N.A.
0
86.6
80
6.6
N.A.
N.A.
13.3
N.A.
6.6
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
0
93.3
86.6
26.6
N.A.
N.A.
26.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
10
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
60
10
0
0
0
0
0
0
0
0
10
0
0
% D
% Glu:
60
10
0
0
0
0
10
0
0
0
10
60
10
0
20
% E
% Phe:
0
10
0
0
10
70
0
10
70
10
0
0
0
0
0
% F
% Gly:
0
0
0
10
0
10
0
0
10
0
0
0
0
0
0
% G
% His:
0
0
0
10
60
0
0
10
0
10
0
0
0
10
10
% H
% Ile:
0
0
0
0
0
0
60
0
0
0
0
0
10
0
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
10
0
10
0
10
0
% K
% Leu:
0
10
0
0
10
0
0
0
10
60
10
10
50
10
40
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
60
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% P
% Gln:
0
0
10
0
0
0
0
0
0
0
10
10
0
0
10
% Q
% Arg:
10
60
10
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
10
60
10
0
10
70
0
0
10
0
10
60
0
% S
% Thr:
10
0
0
10
0
0
10
0
0
0
0
0
0
10
10
% T
% Val:
0
0
10
0
10
10
0
10
0
0
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _