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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: RNF145 All Species: 36.06
Human Site: Y453 Identified Species: 72.12
UniProt: Q96MT1 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96MT1 NP_653327.1 663 75617 Y453 N M D D V I Y Y V N G T Y R L
Chimpanzee Pan troglodytes XP_518069 702 79985 Y492 N M D D V I Y Y V N G T Y R L
Rhesus Macaque Macaca mulatta XP_001082926 688 78619 Y478 N M D D V I Y Y V N G T Y R L
Dog Lupus familis XP_546272 670 76347 Y453 N M D D V I Y Y V N G T Y R L
Cat Felis silvestris
Mouse Mus musculus Q5SWK7 663 74629 Y453 N M D D V I Y Y V N G T Y R L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506623 680 76969 Y453 N M D D V I Y Y V N G T Y R L
Chicken Gallus gallus XP_001233173 684 76990 Y453 N M D D V I Y Y V N G T Y R L
Frog Xenopus laevis Q5BIY5 695 78476 Y453 N V D D A I Y Y V N G T Y R L
Zebra Danio Brachydanio rerio Q7ZWF4 685 77631 Y453 N M D E V I Y Y V N G T Y R L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KRW1 809 89216 G537 L Y Y V R A F G N S V E F C F
Honey Bee Apis mellifera XP_392068 661 75864 L444 L I L F P V S L L V Y L W S H
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786512 686 76228 M458 S L D D V V Y M I Q S L C H I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.3 92.3 95.6 N.A. 93.8 N.A. N.A. 89.1 87.5 81.7 77.9 N.A. 23.8 28.6 N.A. 36.5
Protein Similarity: 100 94.4 93.9 96.5 N.A. 95.7 N.A. N.A. 91.4 90.6 86.6 85.2 N.A. 43.6 50.8 N.A. 59.3
P-Site Identity: 100 100 100 100 N.A. 100 N.A. N.A. 100 100 86.6 93.3 N.A. 0 0 N.A. 26.6
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 100 100 93.3 100 N.A. 20 26.6 N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 9 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 9 9 0 % C
% Asp: 0 0 84 75 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 9 0 0 0 0 0 0 0 9 0 0 0 % E
% Phe: 0 0 0 9 0 0 9 0 0 0 0 0 9 0 9 % F
% Gly: 0 0 0 0 0 0 0 9 0 0 75 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 % H
% Ile: 0 9 0 0 0 75 0 0 9 0 0 0 0 0 9 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 17 9 9 0 0 0 0 9 9 0 0 17 0 0 75 % L
% Met: 0 67 0 0 0 0 0 9 0 0 0 0 0 0 0 % M
% Asn: 75 0 0 0 0 0 0 0 9 75 0 0 0 0 0 % N
% Pro: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % Q
% Arg: 0 0 0 0 9 0 0 0 0 0 0 0 0 75 0 % R
% Ser: 9 0 0 0 0 0 9 0 0 9 9 0 0 9 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 75 0 0 0 % T
% Val: 0 9 0 9 75 17 0 0 75 9 9 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % W
% Tyr: 0 9 9 0 0 0 84 75 0 0 9 0 75 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _