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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
YTHDC1
All Species:
11.52
Human Site:
Y250
Identified Species:
28.15
UniProt:
Q96MU7
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96MU7
NP_001026902.1
727
84700
Y250
E
E
E
E
E
E
E
Y
E
Q
D
E
R
D
Q
Chimpanzee
Pan troglodytes
XP_517262
727
84680
Y250
E
E
E
E
E
E
E
Y
E
Q
D
E
R
D
Q
Rhesus Macaque
Macaca mulatta
XP_001098270
654
76448
S227
A
K
A
K
G
V
W
S
T
L
P
V
N
E
K
Dog
Lupus familis
XP_532391
712
83066
E235
G
E
E
E
E
E
E
E
E
E
E
E
E
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Rat
Rattus norvegicus
Q9QY02
738
85807
Y253
E
E
E
E
E
E
E
Y
E
Q
D
E
R
D
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026318
473
53297
A51
H
M
D
L
P
P
S
A
E
M
N
Y
G
E
L
Frog
Xenopus laevis
NP_001088293
704
81861
R229
E
G
E
E
E
Y
D
R
D
E
H
A
R
D
Q
Zebra Danio
Brachydanio rerio
NP_001007411
679
78642
E217
E
G
D
D
D
D
D
E
E
E
E
Y
V
L
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395221
545
61700
S123
D
E
T
Y
D
T
R
S
E
V
S
S
S
S
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783255
763
85165
D265
E
E
E
E
E
E
E
D
E
E
E
E
G
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
53.2
95.4
N.A.
N.A.
95.3
N.A.
N.A.
51
72
66.5
N.A.
N.A.
28.3
N.A.
34.6
Protein Similarity:
100
99.7
60.1
96.2
N.A.
N.A.
97
N.A.
N.A.
55.2
83.4
78.2
N.A.
N.A.
41.1
N.A.
50.3
P-Site Identity:
100
100
0
53.3
N.A.
N.A.
100
N.A.
N.A.
6.6
46.6
13.3
N.A.
N.A.
13.3
N.A.
60
P-Site Similarity:
100
100
26.6
80
N.A.
N.A.
100
N.A.
N.A.
26.6
66.6
66.6
N.A.
N.A.
26.6
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
0
0
0
10
0
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
20
10
20
10
20
10
10
0
30
0
0
40
10
% D
% Glu:
60
60
60
60
60
50
50
20
80
40
30
50
10
30
20
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
20
0
0
10
0
0
0
0
0
0
0
20
10
0
% G
% His:
10
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
10
0
0
0
0
0
0
0
0
0
0
10
% K
% Leu:
0
0
0
10
0
0
0
0
0
10
0
0
0
10
10
% L
% Met:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% N
% Pro:
0
0
0
0
10
10
0
0
0
0
10
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
30
0
0
0
0
40
% Q
% Arg:
0
0
0
0
0
0
10
10
0
0
0
0
40
0
0
% R
% Ser:
0
0
0
0
0
0
10
20
0
0
10
10
10
10
10
% S
% Thr:
0
0
10
0
0
10
0
0
10
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
10
0
0
0
10
0
10
10
0
0
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
10
0
30
0
0
0
20
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _