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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMEM56 All Species: 25.15
Human Site: Y166 Identified Species: 46.11
UniProt: Q96MV1 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96MV1 NP_689700.1 263 30041 Y166 W F F E A L K Y P K F S K A I
Chimpanzee Pan troglodytes XP_524620 263 30010 Y166 W F F E A L K Y P K F S K A I
Rhesus Macaque Macaca mulatta XP_001103909 263 30144 Y166 W F F E A L K Y P K F S K A I
Dog Lupus familis XP_547272 263 30212 Y166 W F F E A L K Y P K F S K A N
Cat Felis silvestris
Mouse Mus musculus Q8CGF5 276 31217 Y179 W F F E A L K Y P K F S K A N
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518543 135 15202 Y39 W F F E V L K Y P K A S K A N
Chicken Gallus gallus
Frog Xenopus laevis Q6PGS5 262 29834 Y166 W F F E V L G Y S K Y S L P N
Zebra Danio Brachydanio rerio Q5XIY2 264 29909 H167 A L A Y P R T H Q L V V A N G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203034 276 31599 Y175 W M L Y L L G Y K D T K F Y M
Poplar Tree Populus trichocarpa XP_002325620 265 29872 P169 L F S E I T T P F V N L R W Y
Maize Zea mays NP_001149791 268 30861 L168 Q F Y T Y M V L I S E T T T P
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_567355 266 30189 P166 L L S E A T T P F V N L R W Y
Baker's Yeast Sacchar. cerevisiae P47153 279 31993 I183 F V N I N W F I M Q C N A K S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 95.4 80.6 N.A. 73.5 N.A. N.A. 35.7 N.A. 54.3 47.3 N.A. N.A. N.A. N.A. 30.8
Protein Similarity: 100 99.6 97.3 88.9 N.A. 82.6 N.A. N.A. 41.4 N.A. 72.2 67 N.A. N.A. N.A. N.A. 51.8
P-Site Identity: 100 100 100 93.3 N.A. 93.3 N.A. N.A. 80 N.A. 53.3 0 N.A. N.A. N.A. N.A. 20
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 N.A. N.A. 80 N.A. 60 6.6 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: 28.6 28.7 N.A. 26.6 25.4 N.A.
Protein Similarity: 51.3 51.1 N.A. 49.6 48.3 N.A.
P-Site Identity: 13.3 6.6 N.A. 13.3 0 N.A.
P-Site Similarity: 20 26.6 N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 0 47 0 0 0 0 0 8 0 16 47 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % D
% Glu: 0 0 0 70 0 0 0 0 0 0 8 0 0 0 0 % E
% Phe: 8 70 54 0 0 0 8 0 16 0 39 0 8 0 0 % F
% Gly: 0 0 0 0 0 0 16 0 0 0 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 8 0 0 8 8 0 0 0 0 0 24 % I
% Lys: 0 0 0 0 0 0 47 0 8 54 0 8 47 8 0 % K
% Leu: 16 16 8 0 8 62 0 8 0 8 0 16 8 0 0 % L
% Met: 0 8 0 0 0 8 0 0 8 0 0 0 0 0 8 % M
% Asn: 0 0 8 0 8 0 0 0 0 0 16 8 0 8 31 % N
% Pro: 0 0 0 0 8 0 0 16 47 0 0 0 0 8 8 % P
% Gln: 8 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 8 0 0 0 0 0 0 16 0 0 % R
% Ser: 0 0 16 0 0 0 0 0 8 8 0 54 0 0 8 % S
% Thr: 0 0 0 8 0 16 24 0 0 0 8 8 8 8 0 % T
% Val: 0 8 0 0 16 0 8 0 0 16 8 8 0 0 0 % V
% Trp: 62 0 0 0 0 8 0 0 0 0 0 0 0 16 0 % W
% Tyr: 0 0 8 16 8 0 0 62 0 0 8 0 0 8 16 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _