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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NLRP3
All Species:
6.97
Human Site:
S740
Identified Species:
25.56
UniProt:
Q96P20
Number Species:
6
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96P20
NP_001073289.1
1036
118173
S740
L
F
S
V
L
S
T
S
Q
S
L
T
E
L
D
Chimpanzee
Pan troglodytes
Q8HZP9
461
49911
R217
G
V
T
S
D
N
C
R
D
L
C
G
I
V
A
Rhesus Macaque
Macaca mulatta
NP_001107823
1035
118173
S739
L
F
S
V
L
S
T
S
Q
S
L
T
E
L
D
Dog
Lupus familis
XP_848377
1072
123091
S746
F
S
V
L
S
R
N
S
L
S
L
T
E
L
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4B8
1033
118256
N737
L
F
S
S
L
S
T
N
R
S
L
T
E
L
D
Rat
Rattus norvegicus
Q63035
880
98190
L636
D
D
F
V
R
Q
A
L
S
S
L
P
E
M
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517634
964
106853
V714
G
D
Q
P
L
S
P
V
E
K
C
W
L
P
D
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
21.1
97.9
78.9
N.A.
82.8
29.4
N.A.
41.4
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
30.5
98.3
86.6
N.A.
90.3
46
N.A.
56.1
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
100
40
N.A.
80
26.6
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
100
53.3
N.A.
93.3
33.3
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
15
0
0
0
0
0
0
0
15
% A
% Cys:
0
0
0
0
0
0
15
0
0
0
29
0
0
0
0
% C
% Asp:
15
29
0
0
15
0
0
0
15
0
0
0
0
0
58
% D
% Glu:
0
0
0
0
0
0
0
0
15
0
0
0
72
0
0
% E
% Phe:
15
43
15
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
29
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
15
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% K
% Leu:
43
0
0
15
58
0
0
15
15
15
72
0
15
58
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
15
0
% M
% Asn:
0
0
0
0
0
15
15
15
0
0
0
0
0
0
15
% N
% Pro:
0
0
0
15
0
0
15
0
0
0
0
15
0
15
0
% P
% Gln:
0
0
15
0
0
15
0
0
29
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
15
15
0
15
15
0
0
0
0
0
0
% R
% Ser:
0
15
43
29
15
58
0
43
15
72
0
0
0
0
0
% S
% Thr:
0
0
15
0
0
0
43
0
0
0
0
58
0
0
0
% T
% Val:
0
15
15
43
0
0
0
15
0
0
0
0
0
15
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _