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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AP1S3 All Species: 18.18
Human Site: T22 Identified Species: 36.36
UniProt: Q96PC3 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96PC3 NP_001034658 154 18280 T22 R L Q K W Y I T L P D K E R K
Chimpanzee Pan troglodytes XP_001138231 185 21159 L43 A A A M Q F M L L F S R Q G K
Rhesus Macaque Macaca mulatta XP_001098858 228 26008 T96 R L Q K W Y I T L P D K E R K
Dog Lupus familis XP_536088 157 18743 T25 R L Q K W Y T T L P D K E R K
Cat Felis silvestris
Mouse Mus musculus Q7TN05 154 18422 T22 R L Q K W Y T T L P D K E R K
Rat Rattus norvegicus P62744 142 16999 K13 L I Q N R A G K T R L A K W Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001025179 154 18367 T22 R L Q K W Y T T L P E K E K K
Frog Xenopus laevis NP_001088344 160 18927 P21 R L Q K W Y V P L S D K E K K
Zebra Danio Brachydanio rerio NP_001004635 154 18426 P22 R L Q K W F L P L P E R D R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays O50016 132 15996
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P35181 156 18134 A24 R L K K W Y T A M S A G E K A
Red Bread Mold Neurospora crassa Q7SAQ1 143 16937 T14 I Q N R Q G K T R L A K W Y V
Conservation
Percent
Protein Identity: 100 58.9 62.7 87.2 N.A. 88.3 40.9 N.A. N.A. 81.8 68.7 68.8 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 71.8 62.7 88.5 N.A. 90.9 65.5 N.A. N.A. 89.6 85 84.4 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 100 93.3 N.A. 93.3 6.6 N.A. N.A. 80 73.3 60 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 40 100 93.3 N.A. 93.3 20 N.A. N.A. 93.3 86.6 93.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. 38.3 N.A. N.A. 44.8 45.4
Protein Similarity: N.A. 62.3 N.A. N.A. 65.3 67.5
P-Site Identity: N.A. 0 N.A. N.A. 40 13.3
P-Site Similarity: N.A. 0 N.A. N.A. 60 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 9 0 0 9 0 9 0 0 17 9 0 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 42 0 9 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 17 0 59 0 0 % E
% Phe: 0 0 0 0 0 17 0 0 0 9 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 9 9 0 0 0 0 9 0 9 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 9 9 0 0 0 0 17 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 9 67 0 0 9 9 0 0 0 59 9 25 67 % K
% Leu: 9 67 0 0 0 0 9 9 67 9 9 0 0 0 0 % L
% Met: 0 0 0 9 0 0 9 0 9 0 0 0 0 0 0 % M
% Asn: 0 0 9 9 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 17 0 50 0 0 0 0 0 % P
% Gln: 0 9 67 0 17 0 0 0 0 0 0 0 9 0 0 % Q
% Arg: 67 0 0 9 9 0 0 0 9 9 0 17 0 42 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 17 9 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 34 50 9 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 9 % V
% Trp: 0 0 0 0 67 0 0 0 0 0 0 0 9 9 0 % W
% Tyr: 0 0 0 0 0 59 0 0 0 0 0 0 0 9 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _