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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NEDD4L All Species: 14.24
Human Site: S432 Identified Species: 26.11
UniProt: Q96PU5 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96PU5 NP_001138436.1 975 111932 S432 A S G S A T N S N N H L I E P
Chimpanzee Pan troglodytes XP_001140254 911 104904 Q432 K P Q H K V T Q S F L P P G W
Rhesus Macaque Macaca mulatta XP_001088661 1010 115306 S467 A S G S A T N S N N H L I E P
Dog Lupus familis XP_533393 1027 117927 S484 A S G S A T N S N N H L I E P
Cat Felis silvestris
Mouse Mus musculus Q8CFI0 1004 115400 S461 A S G S A T N S N N H L V E P
Rat Rattus norvegicus Q62940 887 102376 K426 Y Y V D H N S K T T T W S K P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511197 1255 141275 L592 A E S G N I Q L Q A Q H A F T
Chicken Gallus gallus XP_424462 1045 119140 N502 M V G S A A N N N N H L S E P
Frog Xenopus laevis Q2TAS2 751 86306 T310 W E I R N T A T G R V Y F V D
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 Q324 D H N N R T T Q F T D P R L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVI3 1007 114856 E471 D V D H R Q Q E P Q H R G Q R
Honey Bee Apis mellifera XP_395191 782 90150 H340 R P S S I P N H I A P S T T P
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 I368 D P R R Q Q Y I R T Y G P T N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.4 92.4 90.8 N.A. 94.3 48 N.A. 43.9 85.6 34.1 34.3 N.A. 47.2 49.4 N.A. N.A.
Protein Similarity: 100 93.4 93.7 92.2 N.A. 95.6 60 N.A. 54 88.4 49 49.5 N.A. 61.8 61.1 N.A. N.A.
P-Site Identity: 100 0 100 100 N.A. 93.3 6.6 N.A. 6.6 66.6 6.6 6.6 N.A. 6.6 20 N.A. N.A.
P-Site Similarity: 100 6.6 100 100 N.A. 100 20 N.A. 6.6 73.3 13.3 13.3 N.A. 13.3 20 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 39 0 0 0 39 8 8 0 0 16 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 24 0 8 8 0 0 0 0 0 0 8 0 0 0 8 % D
% Glu: 0 16 0 0 0 0 0 8 0 0 0 0 0 39 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 8 0 0 8 8 0 % F
% Gly: 0 0 39 8 0 0 0 0 8 0 0 8 8 8 0 % G
% His: 0 8 0 16 8 0 0 8 0 0 47 8 0 0 0 % H
% Ile: 0 0 8 0 8 8 0 8 8 0 0 0 24 0 0 % I
% Lys: 8 0 0 0 8 0 0 8 0 0 0 0 0 8 0 % K
% Leu: 0 0 0 0 0 0 0 8 0 0 8 39 0 8 0 % L
% Met: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 8 16 8 47 8 39 39 0 0 0 0 8 % N
% Pro: 0 24 0 0 0 8 0 0 8 0 8 16 16 0 54 % P
% Gln: 0 0 8 0 8 16 16 16 8 8 8 0 0 8 0 % Q
% Arg: 8 0 8 16 16 0 0 0 8 8 0 8 8 0 8 % R
% Ser: 0 31 16 47 0 0 8 31 8 0 0 8 16 0 8 % S
% Thr: 0 0 0 0 0 47 16 8 8 24 8 0 8 16 8 % T
% Val: 0 16 8 0 0 8 0 0 0 0 8 0 8 8 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 8 0 0 8 % W
% Tyr: 8 8 0 0 0 0 8 0 0 0 8 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _