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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NEDD4L All Species: 18.18
Human Site: S446 Identified Species: 33.33
UniProt: Q96PU5 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96PU5 NP_001138436.1 975 111932 S446 P Q I R R P R S L S S P T V T
Chimpanzee Pan troglodytes XP_001140254 911 104904 N446 W E M R I A P N G R P F F I D
Rhesus Macaque Macaca mulatta XP_001088661 1010 115306 S481 P Q I R R P R S L S S P T V T
Dog Lupus familis XP_533393 1027 117927 S498 P Q I R R P R S L S S P T V T
Cat Felis silvestris
Mouse Mus musculus Q8CFI0 1004 115400 S475 P Q I R R P R S L S S P T V T
Rat Rattus norvegicus Q62940 887 102376 R440 P T M Q D D P R S K I P A H L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511197 1255 141275 D606 T T R R Q I S D E T E I L E N
Chicken Gallus gallus XP_424462 1045 119140 S516 P Q I R R P R S L S S P T V T
Frog Xenopus laevis Q2TAS2 751 86306 Q324 D H N N R T T Q F T D P R L S
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 L338 S A N L H L V L N P S P N G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVI3 1007 114856 P485 R H Q Q Q H R P S N E D T D H
Honey Bee Apis mellifera XP_395191 782 90150 L354 P R S D L D Q L G P L P E G W
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 P382 N T T I Q Q Q P V S Q L G P L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.4 92.4 90.8 N.A. 94.3 48 N.A. 43.9 85.6 34.1 34.3 N.A. 47.2 49.4 N.A. N.A.
Protein Similarity: 100 93.4 93.7 92.2 N.A. 95.6 60 N.A. 54 88.4 49 49.5 N.A. 61.8 61.1 N.A. N.A.
P-Site Identity: 100 6.6 100 100 N.A. 100 13.3 N.A. 6.6 100 13.3 13.3 N.A. 13.3 13.3 N.A. N.A.
P-Site Similarity: 100 33.3 100 100 N.A. 100 26.6 N.A. 20 100 33.3 20 N.A. 33.3 26.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 8 0 0 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 0 0 8 8 16 0 8 0 0 8 8 0 8 8 % D
% Glu: 0 8 0 0 0 0 0 0 8 0 16 0 8 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 8 8 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 16 0 0 0 8 16 0 % G
% His: 0 16 0 0 8 8 0 0 0 0 0 0 0 8 8 % H
% Ile: 0 0 39 8 8 8 0 0 0 0 8 8 0 8 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % K
% Leu: 0 0 0 8 8 8 0 16 39 0 8 8 8 8 16 % L
% Met: 0 0 16 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 16 8 0 0 0 8 8 8 0 0 8 0 8 % N
% Pro: 54 0 0 0 0 39 16 16 0 16 8 70 0 8 0 % P
% Gln: 0 39 8 16 24 8 16 8 0 0 8 0 0 0 0 % Q
% Arg: 8 8 8 54 47 0 47 8 0 8 0 0 8 0 0 % R
% Ser: 8 0 8 0 0 0 8 39 16 47 47 0 0 0 16 % S
% Thr: 8 24 8 0 0 8 8 0 0 16 0 0 47 0 39 % T
% Val: 0 0 0 0 0 0 8 0 8 0 0 0 0 39 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _