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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NEDD4L All Species: 17.27
Human Site: S541 Identified Species: 31.67
UniProt: Q96PU5 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96PU5 NP_001138436.1 975 111932 S541 V H M R S K T S L N P N D L G
Chimpanzee Pan troglodytes XP_001140254 911 104904 F533 A V P Y S R E F K Q K Y D Y F
Rhesus Macaque Macaca mulatta XP_001088661 1010 115306 S576 V H M R S K T S L N P N D L G
Dog Lupus familis XP_533393 1027 117927 S593 V H M R S K A S L N P N D L G
Cat Felis silvestris
Mouse Mus musculus Q8CFI0 1004 115400 S570 V H M R S K A S L N P N D L G
Rat Rattus norvegicus Q62940 887 102376 N527 K K Q T D I P N K F E M K L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511197 1255 141275 S821 A H L R R K T S L D P I D L G
Chicken Gallus gallus XP_424462 1045 119140 D611 I A D M M S A D S Y A F G M G
Frog Xenopus laevis Q2TAS2 751 86306 R411 E I F E E S Y R Q V M K M R P
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 R425 E I F E E S Y R Q V M K M R P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVI3 1007 114856 R573 S P M P N Q T R R V E D D L G
Honey Bee Apis mellifera XP_395191 782 90150 I441 I L E D S Y R I I S S V N R V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 Y469 K N I F E D A Y Q E I M R Q T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.4 92.4 90.8 N.A. 94.3 48 N.A. 43.9 85.6 34.1 34.3 N.A. 47.2 49.4 N.A. N.A.
Protein Similarity: 100 93.4 93.7 92.2 N.A. 95.6 60 N.A. 54 88.4 49 49.5 N.A. 61.8 61.1 N.A. N.A.
P-Site Identity: 100 13.3 100 93.3 N.A. 93.3 6.6 N.A. 66.6 6.6 0 0 N.A. 33.3 6.6 N.A. N.A.
P-Site Similarity: 100 20 100 93.3 N.A. 93.3 13.3 N.A. 80 20 0 0 N.A. 53.3 33.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 0 0 0 0 31 0 0 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 8 8 8 0 8 0 8 0 8 54 0 0 % D
% Glu: 16 0 8 16 24 0 8 0 0 8 16 0 0 0 0 % E
% Phe: 0 0 16 8 0 0 0 8 0 8 0 8 0 0 8 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 54 % G
% His: 0 39 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 16 16 8 0 0 8 0 8 8 0 8 8 0 0 0 % I
% Lys: 16 8 0 0 0 39 0 0 16 0 8 16 8 0 0 % K
% Leu: 0 8 8 0 0 0 0 0 39 0 0 0 0 54 0 % L
% Met: 0 0 39 8 8 0 0 0 0 0 16 16 16 8 0 % M
% Asn: 0 8 0 0 8 0 0 8 0 31 0 31 8 0 0 % N
% Pro: 0 8 8 8 0 0 8 0 0 0 39 0 0 0 16 % P
% Gln: 0 0 8 0 0 8 0 0 24 8 0 0 0 8 0 % Q
% Arg: 0 0 0 39 8 8 8 24 8 0 0 0 8 24 8 % R
% Ser: 8 0 0 0 47 24 0 39 8 8 8 0 0 0 0 % S
% Thr: 0 0 0 8 0 0 31 0 0 0 0 0 0 0 8 % T
% Val: 31 8 0 0 0 0 0 0 0 24 0 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 0 8 16 8 0 8 0 8 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _