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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NEDD4L All Species: 20.61
Human Site: Y380 Identified Species: 37.78
UniProt: Q96PU5 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96PU5 NP_001138436.1 975 111932 Y380 E P T P S V A Y V H T T P G L
Chimpanzee Pan troglodytes XP_001140254 911 104904 P380 I E P Q I R R P R S L S S P T
Rhesus Macaque Macaca mulatta XP_001088661 1010 115306 Y415 E P T P S V A Y V H T T P G L
Dog Lupus familis XP_533393 1027 117927 Y432 E P T P S V A Y A H T T P G L
Cat Felis silvestris
Mouse Mus musculus Q8CFI0 1004 115400 Y409 E P T P S V A Y V H T T P G L
Rat Rattus norvegicus Q62940 887 102376 S374 T S Q P V T S S N H S S R G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511197 1255 141275 Q540 D A A C H L Q Q Q Q E S S P L
Chicken Gallus gallus XP_424462 1045 119140 Y450 E P T P S V A Y V H T T P G L
Frog Xenopus laevis Q2TAS2 751 86306 E258 P D L P E G Y E Q R T T Q Q G
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 T272 G Q V Y F L H T Q T G V S T W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVI3 1007 114856 F419 D I A I T N P F T R R A A G N
Honey Bee Apis mellifera XP_395191 782 90150 S288 R S S E Q I E S P K P V I P A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 A316 I P P V N G A A A A A F A A T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.4 92.4 90.8 N.A. 94.3 48 N.A. 43.9 85.6 34.1 34.3 N.A. 47.2 49.4 N.A. N.A.
Protein Similarity: 100 93.4 93.7 92.2 N.A. 95.6 60 N.A. 54 88.4 49 49.5 N.A. 61.8 61.1 N.A. N.A.
P-Site Identity: 100 0 100 93.3 N.A. 100 20 N.A. 6.6 100 20 0 N.A. 6.6 0 N.A. N.A.
P-Site Similarity: 100 6.6 100 93.3 N.A. 100 40 N.A. 26.6 100 20 6.6 N.A. 26.6 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 16 0 0 0 47 8 16 8 8 8 16 8 8 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 16 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 39 8 0 8 8 0 8 8 0 0 8 0 0 0 0 % E
% Phe: 0 0 0 0 8 0 0 8 0 0 0 8 0 0 0 % F
% Gly: 8 0 0 0 0 16 0 0 0 0 8 0 0 54 16 % G
% His: 0 0 0 0 8 0 8 0 0 47 0 0 0 0 0 % H
% Ile: 16 8 0 8 8 8 0 0 0 0 0 0 8 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % K
% Leu: 0 0 8 0 0 16 0 0 0 0 8 0 0 0 47 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 8 0 0 8 0 0 0 0 0 8 % N
% Pro: 8 47 16 54 0 0 8 8 8 0 8 0 39 24 0 % P
% Gln: 0 8 8 8 8 0 8 8 24 8 0 0 8 8 0 % Q
% Arg: 8 0 0 0 0 8 8 0 8 16 8 0 8 0 0 % R
% Ser: 0 16 8 0 39 0 8 16 0 8 8 24 24 0 0 % S
% Thr: 8 0 39 0 8 8 0 8 8 8 47 47 0 8 16 % T
% Val: 0 0 8 8 8 39 0 0 31 0 0 16 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % W
% Tyr: 0 0 0 8 0 0 8 39 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _