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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NR1H4
All Species:
35.76
Human Site:
T456
Identified Species:
65.56
UniProt:
Q96RI1
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96RI1
NP_005114.1
486
55914
T456
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
Chimpanzee
Pan troglodytes
XP_509299
482
55475
T452
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
Rhesus Macaque
Macaca mulatta
XP_001090182
482
55476
T452
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
Dog
Lupus familis
XP_866622
455
52340
T425
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Q60641
488
56018
T458
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
Rat
Rattus norvegicus
Q62735
469
53916
T439
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506579
453
52254
T423
G
R
L
T
E
L
R
T
F
N
H
H
H
A
E
Chicken
Gallus gallus
P22448
455
50690
T426
G
H
E
P
L
T
P
T
S
N
G
N
T
A
E
Frog
Xenopus laevis
P18119
414
46688
C387
D
L
R
M
I
G
A
C
H
A
S
R
F
L
H
Zebra Danio
Brachydanio rerio
Q9PTN2
453
50848
E421
A
D
L
R
S
L
N
E
E
H
S
K
Q
Y
R
Tiger Blowfish
Takifugu rubipres
Q9W5Z3
447
49514
R420
E
S
G
A
T
G
S
R
P
S
G
A
P
P
G
Fruit Fly
Dros. melanogaster
P34021
878
93835
T623
S
I
L
T
E
L
R
T
L
G
N
Q
N
A
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123279
490
55735
S460
M
K
L
T
E
L
R
S
L
N
N
S
H
S
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97.3
88.6
N.A.
92.2
86.8
N.A.
81.2
28.3
26.3
20.9
29.6
22.5
N.A.
N.A.
40.2
Protein Similarity:
100
99.1
98.5
91.3
N.A.
95.6
91.9
N.A.
86.8
46.2
44.4
40.5
47.3
34.4
N.A.
N.A.
57.9
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
33.3
0
13.3
0
53.3
N.A.
N.A.
53.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
40
0
20
6.6
66.6
N.A.
N.A.
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
0
0
8
0
0
8
0
8
0
70
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
8
0
70
0
0
8
8
0
0
0
0
0
77
% E
% Phe:
0
0
0
0
0
0
0
0
54
0
0
0
8
0
0
% F
% Gly:
62
0
8
0
0
16
0
0
0
8
16
0
0
0
8
% G
% His:
0
8
0
0
0
0
0
0
8
8
54
54
62
0
8
% H
% Ile:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% K
% Leu:
0
8
77
0
8
77
0
0
16
0
0
0
0
8
0
% L
% Met:
8
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
70
16
8
8
0
0
% N
% Pro:
0
0
0
8
0
0
8
0
8
0
0
0
8
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
8
0
0
% Q
% Arg:
0
54
8
8
0
0
70
8
0
0
0
8
0
0
8
% R
% Ser:
8
8
0
0
8
0
8
8
8
8
16
8
0
8
0
% S
% Thr:
0
0
0
70
8
8
0
70
0
0
0
0
8
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _