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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NR1H4
All Species:
20.3
Human Site:
Y274
Identified Species:
37.22
UniProt:
Q96RI1
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96RI1
NP_005114.1
486
55914
Y274
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
Chimpanzee
Pan troglodytes
XP_509299
482
55475
Y270
L
H
F
I
M
D
S
Y
N
K
Q
R
M
P
Q
Rhesus Macaque
Macaca mulatta
XP_001090182
482
55476
Y270
L
H
Y
I
M
D
S
Y
S
K
Q
K
M
P
Q
Dog
Lupus familis
XP_866622
455
52340
N266
E
E
F
S
A
E
E
N
F
L
I
L
T
E
M
Cat
Felis silvestris
Mouse
Mus musculus
Q60641
488
56018
Y276
L
D
Y
I
M
D
S
Y
N
K
Q
R
M
P
Q
Rat
Rattus norvegicus
Q62735
469
53916
Y257
L
D
Y
I
M
D
S
Y
S
K
Q
R
M
P
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506579
453
52254
D263
K
E
E
F
S
A
E
D
N
F
L
I
L
T
E
Chicken
Gallus gallus
P22448
455
50690
A264
Q
I
T
L
L
K
A
A
C
L
D
I
L
I
L
Frog
Xenopus laevis
P18119
414
46688
P231
Q
F
T
K
I
I
T
P
A
I
T
R
V
V
D
Zebra Danio
Brachydanio rerio
Q9PTN2
453
50848
S265
L
A
D
L
V
S
Y
S
I
Q
K
V
I
G
F
Tiger Blowfish
Takifugu rubipres
Q9W5Z3
447
49514
I260
L
K
A
A
C
L
D
I
L
I
L
R
I
C
T
Fruit Fly
Dros. melanogaster
P34021
878
93835
Q436
W
Y
Q
D
G
Y
E
Q
P
S
E
E
D
L
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123279
490
55735
T275
G
L
M
P
V
S
L
T
P
K
R
S
E
D
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
97.3
88.6
N.A.
92.2
86.8
N.A.
81.2
28.3
26.3
20.9
29.6
22.5
N.A.
N.A.
40.2
Protein Similarity:
100
99.1
98.5
91.3
N.A.
95.6
91.9
N.A.
86.8
46.2
44.4
40.5
47.3
34.4
N.A.
N.A.
57.9
P-Site Identity:
100
100
80
6.6
N.A.
86.6
80
N.A.
6.6
0
6.6
6.6
13.3
0
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
13.3
N.A.
93.3
93.3
N.A.
20
26.6
26.6
40
20
20
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
8
8
8
8
8
8
8
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
8
0
0
0
0
8
0
% C
% Asp:
0
16
8
8
0
39
8
8
0
0
8
0
8
8
8
% D
% Glu:
8
16
8
0
0
8
24
0
0
0
8
8
8
8
8
% E
% Phe:
0
8
24
8
0
0
0
0
8
8
0
0
0
0
8
% F
% Gly:
8
0
0
0
8
0
0
0
0
0
0
0
0
8
8
% G
% His:
0
24
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
39
8
8
0
8
8
16
8
16
16
8
0
% I
% Lys:
8
8
0
8
0
8
0
0
0
47
8
8
0
0
0
% K
% Leu:
54
8
0
16
8
8
8
0
8
16
16
8
16
8
8
% L
% Met:
0
0
8
0
39
0
0
0
0
0
0
0
39
0
8
% M
% Asn:
0
0
0
0
0
0
0
8
31
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
0
0
8
16
0
0
0
0
39
0
% P
% Gln:
16
0
8
0
0
0
0
8
0
8
39
0
0
0
39
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
8
47
0
0
8
% R
% Ser:
0
0
0
8
8
16
39
8
16
8
0
8
0
0
0
% S
% Thr:
0
0
16
0
0
0
8
8
0
0
8
0
8
8
8
% T
% Val:
0
0
0
0
16
0
0
0
0
0
0
8
8
8
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
24
0
0
8
8
39
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _