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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS13A All Species: 25.15
Human Site: Y2888 Identified Species: 61.48
UniProt: Q96RL7 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96RL7 NP_001018047.1 3174 360276 Y2888 E A F F Y E P Y Q G A I Q G P
Chimpanzee Pan troglodytes XP_001148547 3174 360353 Y2888 E A F F Y E P Y Q G A I Q G P
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_533522 3194 361576 Y2907 E A F F Y E P Y Q G A I Q G P
Cat Felis silvestris
Mouse Mus musculus Q5H8C4 3166 359382 Y2880 E A F F Y E P Y Q G A I Q G P
Rat Rattus norvegicus NP_001094445 3167 360039 Y2881 E A F F Y E P Y Q G A I Q G P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511611 3012 340425 N2771 K L A Y F E L N Y Q F H T R P
Chicken Gallus gallus XP_001233000 3758 422392 F3449 E A F F Y E P F Q G A V Q G P
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001112365 3194 360237 Y2908 E A F F Y E P Y Q G A I Q G P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_610299 3321 374527 F3019 E D L F Y E P F Q G A I Q G P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q07878 3144 357831 Y2863 W D L F Y E P Y Q G Y M M N D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 84.1 N.A. 84.3 84.4 N.A. 61.5 36.9 N.A. 57.3 N.A. 30.4 N.A. N.A. N.A.
Protein Similarity: 100 99.8 N.A. 90.6 N.A. 92.1 92.3 N.A. 76.6 54.5 N.A. 73.8 N.A. 52.2 N.A. N.A. N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. 13.3 86.6 N.A. 100 N.A. 80 N.A. N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. 33.3 100 N.A. 100 N.A. 86.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 41.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 46.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 70 10 0 0 0 0 0 0 0 80 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 20 0 0 0 0 0 0 0 0 0 0 0 0 10 % D
% Glu: 80 0 0 0 0 100 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 70 90 10 0 0 20 0 0 10 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 90 0 0 0 80 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 70 0 0 0 % I
% Lys: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 10 20 0 0 0 10 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % M
% Asn: 0 0 0 0 0 0 0 10 0 0 0 0 0 10 0 % N
% Pro: 0 0 0 0 0 0 90 0 0 0 0 0 0 0 90 % P
% Gln: 0 0 0 0 0 0 0 0 90 10 0 0 80 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % V
% Trp: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 90 0 0 70 10 0 10 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _