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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCNX All Species: 21.52
Human Site: S1216 Identified Species: 39.44
UniProt: Q96RV3 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96RV3 NP_055797.2 2341 258676 S1216 S Y H L S R Q S S D P S V L F
Chimpanzee Pan troglodytes XP_510039 2300 254005 S1183 S D P S V L F S L V Q S K I F
Rhesus Macaque Macaca mulatta XP_001084081 2342 258864 S1217 S Y H L S R Q S S D P S V L F
Dog Lupus familis XP_537501 2332 257280 S1207 S Y H L S R Q S S D P S V L F
Cat Felis silvestris
Mouse Mus musculus Q9QYC1 2344 258128 S1219 S Y H L S R Q S S D P S V L F
Rat Rattus norvegicus NP_001163818 2343 257924 S1218 S Y H L S R Q S S D P S V L F
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423893 2312 255194 S1185 V L F S L V Q S K F F P N S E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923995 2285 252748 N1189 F P N V K D K N P E D P L S E
Tiger Blowfish Takifugu rubipres Q98UF7 1703 191329 V630 R Q S S D P S V L M Y V P L S
Fruit Fly Dros. melanogaster P18490 3433 367590 G1780 G I L G T G T G T G T G T T E
Honey Bee Apis mellifera XP_624687 2092 236172 G1018 H I D I H L F G G N A S T S L
Nematode Worm Caenorhab. elegans NP_492790 1634 183268 I561 K L M Y F E A I H L W M V A I
Sea Urchin Strong. purpuratus XP_001195494 2799 311472 S1269 Y H L S R S A S N P G V V W S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.6 98.7 94.4 N.A. 90.9 91.1 N.A. N.A. 84.9 N.A. 66.7 54.4 29.4 38.7 27.7 35.5
Protein Similarity: 100 98.1 99.4 96.4 N.A. 95.5 95.3 N.A. N.A. 90.8 N.A. 77.7 63 42.9 55.5 41.8 49.2
P-Site Identity: 100 26.6 100 100 N.A. 100 100 N.A. N.A. 13.3 N.A. 0 6.6 0 6.6 6.6 13.3
P-Site Similarity: 100 33.3 100 100 N.A. 100 100 N.A. N.A. 13.3 N.A. 40 6.6 13.3 20 6.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 16 0 0 0 8 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 8 0 8 8 0 0 0 39 8 0 0 0 0 % D
% Glu: 0 0 0 0 0 8 0 0 0 8 0 0 0 0 24 % E
% Phe: 8 0 8 0 8 0 16 0 0 8 8 0 0 0 47 % F
% Gly: 8 0 0 8 0 8 0 16 8 8 8 8 0 0 0 % G
% His: 8 8 39 0 8 0 0 0 8 0 0 0 0 0 0 % H
% Ile: 0 16 0 8 0 0 0 8 0 0 0 0 0 8 8 % I
% Lys: 8 0 0 0 8 0 8 0 8 0 0 0 8 0 0 % K
% Leu: 0 16 16 39 8 16 0 0 16 8 0 0 8 47 8 % L
% Met: 0 0 8 0 0 0 0 0 0 8 0 8 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 8 8 8 0 0 8 0 0 % N
% Pro: 0 8 8 0 0 8 0 0 8 8 39 16 8 0 0 % P
% Gln: 0 8 0 0 0 0 47 0 0 0 8 0 0 0 0 % Q
% Arg: 8 0 0 0 8 39 0 0 0 0 0 0 0 0 0 % R
% Ser: 47 0 8 31 39 8 8 62 39 0 0 54 0 24 16 % S
% Thr: 0 0 0 0 8 0 8 0 8 0 8 0 16 8 0 % T
% Val: 8 0 0 8 8 8 0 8 0 8 0 16 54 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % W
% Tyr: 8 39 0 8 0 0 0 0 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _