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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PCNX All Species: 10
Human Site: S451 Identified Species: 18.33
UniProt: Q96RV3 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96RV3 NP_055797.2 2341 258676 S451 A S D K R T S S E K I A M E A
Chimpanzee Pan troglodytes XP_510039 2300 254005 A449 S T F A S E E A N K N P H A N
Rhesus Macaque Macaca mulatta XP_001084081 2342 258864 S452 A S D K R T S S E K I A M E A
Dog Lupus familis XP_537501 2332 257280 K459 N S G V Q E A K D S S T S D D
Cat Felis silvestris
Mouse Mus musculus Q9QYC1 2344 258128 S453 R A D D R R T S S D K T A P E
Rat Rattus norvegicus NP_001163818 2343 257924 S453 A T D R R T S S D K T A L E G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_423893 2312 255194 A452 E A N K N P H A N E L T T Q A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001923995 2285 252748 G452 L N S E S Q Q G E G T V E A T
Tiger Blowfish Takifugu rubipres Q98UF7 1703 191329
Fruit Fly Dros. melanogaster P18490 3433 367590 A723 E H S D E K T A H E E H G D D
Honey Bee Apis mellifera XP_624687 2092 236172 N285 I N T T D D N N L P L H P Q S
Nematode Worm Caenorhab. elegans NP_492790 1634 183268
Sea Urchin Strong. purpuratus XP_001195494 2799 311472 D469 S K K H S N S D K S E R K K H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.6 98.7 94.4 N.A. 90.9 91.1 N.A. N.A. 84.9 N.A. 66.7 54.4 29.4 38.7 27.7 35.5
Protein Similarity: 100 98.1 99.4 96.4 N.A. 95.5 95.3 N.A. N.A. 90.8 N.A. 77.7 63 42.9 55.5 41.8 49.2
P-Site Identity: 100 6.6 100 6.6 N.A. 20 60 N.A. N.A. 13.3 N.A. 6.6 0 0 0 0 6.6
P-Site Similarity: 100 26.6 100 33.3 N.A. 33.3 86.6 N.A. N.A. 53.3 N.A. 20 0 26.6 40 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 16 0 8 0 0 8 24 0 0 0 24 8 16 24 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 31 16 8 8 0 8 16 8 0 0 0 16 16 % D
% Glu: 16 0 0 8 8 16 8 0 24 16 16 0 8 24 8 % E
% Phe: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 8 0 0 0 0 8 0 8 0 0 8 0 8 % G
% His: 0 8 0 8 0 0 8 0 8 0 0 16 8 0 8 % H
% Ile: 8 0 0 0 0 0 0 0 0 0 16 0 0 0 0 % I
% Lys: 0 8 8 24 0 8 0 8 8 31 8 0 8 8 0 % K
% Leu: 8 0 0 0 0 0 0 0 8 0 16 0 8 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 16 0 0 % M
% Asn: 8 16 8 0 8 8 8 8 16 0 8 0 0 0 8 % N
% Pro: 0 0 0 0 0 8 0 0 0 8 0 8 8 8 0 % P
% Gln: 0 0 0 0 8 8 8 0 0 0 0 0 0 16 0 % Q
% Arg: 8 0 0 8 31 8 0 0 0 0 0 8 0 0 0 % R
% Ser: 16 24 16 0 24 0 31 31 8 16 8 0 8 0 8 % S
% Thr: 0 16 8 8 0 24 16 0 0 0 16 24 8 0 8 % T
% Val: 0 0 0 8 0 0 0 0 0 0 0 8 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _