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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC22A12 All Species: 10.3
Human Site: S62 Identified Species: 25.19
UniProt: Q96S37 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96S37 NP_653186.2 553 59630 S62 D N S T A Q A S I L G S L S P
Chimpanzee Pan troglodytes XP_001165302 553 59615 G62 D N S T A Q A G I L G S L S P
Rhesus Macaque Macaca mulatta XP_001114815 545 58752 G62 D N S T A Q A G V P G G L T P
Dog Lupus familis XP_540882 533 57582 S62 D N S T D Q A S V P G T L S L
Cat Felis silvestris
Mouse Mus musculus Q8CFZ5 553 60176 S62 D N S T S Q A S I P G D L G P
Rat Rattus norvegicus Q3ZAV1 553 60226 S62 D N S T S Q A S I P G D F G R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507099 556 61556 G62 D N H T G S S G V L G N L S T
Chicken Gallus gallus
Frog Xenopus laevis Q66J54 558 62434 D62 W Y Q S N N T D R M G Y V R L
Zebra Danio Brachydanio rerio Q6NYN7 560 61953 A62 L S M S S T D A V D V L R A T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VCA2 548 60985 E60 Y E N G S I Y E L S P H L W N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 88 80.2 N.A. 73.9 74.1 N.A. 48.3 N.A. 40.5 41.9 N.A. 31.8 N.A. N.A. N.A.
Protein Similarity: 100 99.4 90.5 86.6 N.A. 83.5 83.9 N.A. 64.7 N.A. 63.4 63.5 N.A. 52 N.A. N.A. N.A.
P-Site Identity: 100 93.3 66.6 66.6 N.A. 73.3 60 N.A. 46.6 N.A. 6.6 0 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 93.3 80 80 N.A. 80 66.6 N.A. 66.6 N.A. 26.6 40 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 30 0 60 10 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 70 0 0 0 10 0 10 10 0 10 0 20 0 0 0 % D
% Glu: 0 10 0 0 0 0 0 10 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % F
% Gly: 0 0 0 10 10 0 0 30 0 0 80 10 0 20 0 % G
% His: 0 0 10 0 0 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 0 0 0 0 0 10 0 0 40 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 10 0 0 0 0 0 0 0 10 30 0 10 70 0 20 % L
% Met: 0 0 10 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 0 70 10 0 10 10 0 0 0 0 0 10 0 0 10 % N
% Pro: 0 0 0 0 0 0 0 0 0 40 10 0 0 0 40 % P
% Gln: 0 0 10 0 0 60 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 10 0 0 0 10 10 10 % R
% Ser: 0 10 60 20 40 10 10 40 0 10 0 20 0 40 0 % S
% Thr: 0 0 0 70 0 10 10 0 0 0 0 10 0 10 20 % T
% Val: 0 0 0 0 0 0 0 0 40 0 10 0 10 0 0 % V
% Trp: 10 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % W
% Tyr: 10 10 0 0 0 0 10 0 0 0 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _