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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMC6 All Species: 16.67
Human Site: S411 Identified Species: 33.33
UniProt: Q96SB8 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96SB8 NP_001135758.1 1091 126326 S411 L E R Q K K I S W L K E R V K
Chimpanzee Pan troglodytes XP_001136387 1091 126280 S411 L E R Q K K I S W L K E R V K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532882 1606 180795 S926 L E R Q K K I S W L K E R V K
Cat Felis silvestris
Mouse Mus musculus Q924W5 1097 127179 C417 L E R Q K R I C W L K E K V K
Rat Rattus norvegicus NP_001101484 1097 127259 C417 L E R Q K R I C W L K E K V K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505822 579 67328
Chicken Gallus gallus XP_419962 1096 127736 T419 L E K Q R K I T Q L K E K L K
Frog Xenopus laevis Q6P9I7 1128 130494 N450 M A R Q K E I N Q I R E R M K
Zebra Danio Brachydanio rerio NP_001121806 1090 126266 N415 Q A R V E K M N H I Q A E L E
Tiger Blowfish Takifugu rubipres Q802R8 1090 124790 A418 Q A R M E R I A Q I E A A L E
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_794820 1236 142110 S493 L E R E R R V S A L M E E K R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q12749 1114 127990 E444 D Q M R Q E L E Q L E K A N E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 N.A. 63.3 N.A. 90 90.4 N.A. 38.1 59.7 60.5 51.4 45.9 N.A. N.A. N.A. 30.2
Protein Similarity: 100 100 N.A. 66.1 N.A. 96.3 96.2 N.A. 44 77.9 76.7 70.3 67 N.A. N.A. N.A. 50.9
P-Site Identity: 100 100 N.A. 100 N.A. 80 80 N.A. 0 60 46.6 13.3 13.3 N.A. N.A. N.A. 40
P-Site Similarity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. 0 93.3 86.6 60 60 N.A. N.A. N.A. 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 25 0 0 0 0 0 9 9 0 0 17 17 0 0 % A
% Cys: 0 0 0 0 0 0 0 17 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 59 0 9 17 17 0 9 0 0 17 67 17 0 25 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 67 0 0 25 0 0 0 0 0 % I
% Lys: 0 0 9 0 50 42 0 0 0 0 50 9 25 9 59 % K
% Leu: 59 0 0 0 0 0 9 0 0 67 0 0 0 25 0 % L
% Met: 9 0 9 9 0 0 9 0 0 0 9 0 0 9 0 % M
% Asn: 0 0 0 0 0 0 0 17 0 0 0 0 0 9 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 17 9 0 59 9 0 0 0 34 0 9 0 0 0 0 % Q
% Arg: 0 0 75 9 17 34 0 0 0 0 9 0 34 0 9 % R
% Ser: 0 0 0 0 0 0 0 34 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % T
% Val: 0 0 0 9 0 0 9 0 0 0 0 0 0 42 0 % V
% Trp: 0 0 0 0 0 0 0 0 42 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _