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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: IWS1 All Species: 18.18
Human Site: S144 Identified Species: 30.77
UniProt: Q96ST2 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96ST2 NP_060439.2 819 91955 S144 E L L N G H A S D S E N E D V
Chimpanzee Pan troglodytes XP_001139705 1089 121835 S414 E L L N G H A S D S E N E D V
Rhesus Macaque Macaca mulatta XP_001087787 827 93220 S144 E L L N G H A S D S E N E D V
Dog Lupus familis XP_533312 832 93567 S144 E L L N G H A S D S E N E D V
Cat Felis silvestris
Mouse Mus musculus Q8C1D8 766 85230 D132 L L N G H A S D S E K E E V S
Rat Rattus norvegicus Q3SWT4 764 85429 H129 K E E L L N G H A S D S E K E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510535 927 102715 S237 E T R K P P P S D S D I E D P
Chicken Gallus gallus XP_422571 689 77823 D55 R S E N E H S D G E D D G Q M
Frog Xenopus laevis Q6DE96 836 92684 S166 R H I K K T A S D S E D E A P
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097000 820 90557 P146 S R H S G A A P G S P A G S R
Honey Bee Apis mellifera XP_624549 770 87091 R136 P G G S P C S R R S R S R S R
Nematode Worm Caenorhab. elegans Q19375 511 57235
Sea Urchin Strong. purpuratus XP_798740 798 90991 E147 Y E Q I L S D E E Q I D Y D D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q06505 410 46064
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 74.7 94.3 93.8 N.A. 84.7 82.4 N.A. 69.6 65 60.4 N.A. N.A. 26.5 30.1 22.7 31.5
Protein Similarity: 100 74.8 96.1 95.3 N.A. 88.4 87.1 N.A. 75.8 73.7 72.9 N.A. N.A. 46.7 48.8 37.3 50.9
P-Site Identity: 100 100 100 100 N.A. 13.3 13.3 N.A. 40 13.3 40 N.A. N.A. 20 6.6 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 26.6 40 N.A. 46.6 40 53.3 N.A. N.A. 26.6 26.6 0 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 21.1 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 32.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 15 43 0 8 0 0 8 0 8 0 % A
% Cys: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 8 15 43 0 22 22 0 43 8 % D
% Glu: 36 15 15 0 8 0 0 8 8 15 36 8 58 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 8 8 36 0 8 0 15 0 0 0 15 0 0 % G
% His: 0 8 8 0 8 36 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 8 0 0 0 0 0 0 8 8 0 0 0 % I
% Lys: 8 0 0 15 8 0 0 0 0 0 8 0 0 8 0 % K
% Leu: 8 36 29 8 15 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 0 8 36 0 8 0 0 0 0 0 29 0 0 0 % N
% Pro: 8 0 0 0 15 8 8 8 0 0 8 0 0 0 15 % P
% Gln: 0 0 8 0 0 0 0 0 0 8 0 0 0 8 0 % Q
% Arg: 15 8 8 0 0 0 0 8 8 0 8 0 8 0 15 % R
% Ser: 8 8 0 15 0 8 22 43 8 65 0 15 0 15 8 % S
% Thr: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 29 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _