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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IWS1
All Species:
19.7
Human Site:
S377
Identified Species:
33.33
UniProt:
Q96ST2
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96ST2
NP_060439.2
819
91955
S377
H
K
K
Q
K
M
D
S
D
E
D
E
K
E
G
Chimpanzee
Pan troglodytes
XP_001139705
1089
121835
S647
H
K
K
Q
K
M
D
S
D
E
D
E
K
E
G
Rhesus Macaque
Macaca mulatta
XP_001087787
827
93220
S377
P
K
K
Q
K
L
D
S
D
E
D
E
K
E
G
Dog
Lupus familis
XP_533312
832
93567
S388
P
K
R
P
K
I
E
S
D
E
D
E
E
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8C1D8
766
85230
A363
K
S
R
V
V
C
D
A
D
D
S
D
S
D
V
Rat
Rattus norvegicus
Q3SWT4
764
85429
S360
A
K
K
S
R
V
I
S
D
A
D
D
S
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510535
927
102715
S485
P
K
R
Q
K
I
D
S
D
E
E
G
G
K
E
Chicken
Gallus gallus
XP_422571
689
77823
V286
K
V
R
I
L
S
D
V
E
E
S
D
S
D
A
Frog
Xenopus laevis
Q6DE96
836
92684
A397
S
D
E
E
G
E
K
A
S
K
K
K
K
S
N
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097000
820
90557
R377
S
R
S
R
S
G
S
R
R
S
R
S
G
S
R
Honey Bee
Apis mellifera
XP_624549
770
87091
S367
H
S
P
T
R
S
R
S
R
S
V
S
V
A
G
Nematode Worm
Caenorhab. elegans
Q19375
511
57235
R108
A
E
E
S
A
N
K
R
A
L
I
D
S
D
A
Sea Urchin
Strong. purpuratus
XP_798740
798
90991
D378
S
D
D
D
D
E
D
D
V
I
G
R
S
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q06505
410
46064
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.7
94.3
93.8
N.A.
84.7
82.4
N.A.
69.6
65
60.4
N.A.
N.A.
26.5
30.1
22.7
31.5
Protein Similarity:
100
74.8
96.1
95.3
N.A.
88.4
87.1
N.A.
75.8
73.7
72.9
N.A.
N.A.
46.7
48.8
37.3
50.9
P-Site Identity:
100
100
86.6
46.6
N.A.
13.3
33.3
N.A.
46.6
13.3
6.6
N.A.
N.A.
0
20
0
6.6
P-Site Similarity:
100
100
93.3
80
N.A.
46.6
60
N.A.
73.3
40
40
N.A.
N.A.
13.3
26.6
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
0
0
0
8
0
0
15
8
8
0
0
0
8
15
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
15
8
8
8
0
50
8
50
8
36
29
0
29
0
% D
% Glu:
0
8
15
8
0
15
8
0
8
43
8
29
8
22
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
8
0
0
0
0
8
8
15
0
29
% G
% His:
22
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
15
8
0
0
8
8
0
0
0
0
% I
% Lys:
15
43
29
0
36
0
15
0
0
8
8
8
29
22
0
% K
% Leu:
0
0
0
0
8
8
0
0
0
8
0
0
0
0
0
% L
% Met:
0
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% N
% Pro:
22
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
29
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
29
8
15
0
8
15
15
0
8
8
0
0
8
% R
% Ser:
22
15
8
15
8
15
8
50
8
15
15
15
36
15
15
% S
% Thr:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
8
0
8
8
8
0
8
8
0
8
0
8
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _